ArticleJournal of applied physiology (Bethesda, Md. : 1985)2015
Impaired myocardial function does not explain reduced left ventricular filling and stroke volume at rest or during exercise at high altitude.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Right Ventricular Response to Acute Hypoxia Exposure: A Systematic Review.Frontiers in physiology · 2021Pooled it
- The independent effects of hypovolaemia and pulmonary vasoconstriction on ventricular function and exercise capacity during acclimatisation to 3800 m.The Journal of physiology · 2019Trial
- Acute Hypoxic Exposure and Right Ventricular Adaptation: Morphological Remodeling, Functional Dynamics, and Hemodynamic Implications in Healthy Individuals.Physiological research · 2025Review
- Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype.Communications biology · 2024Article
- Hypoxic pulmonary vasoconstriction does not limit maximal exercise capacity in healthy volunteers breathing 12% oxygen at sea level.Physiological reports · 2024Article
- The impact of high-altitude migration on cardiac structure and function: a 1-year prospective study.Frontiers in physiology · 2024Article
- Left Ventricular Responses during Exercise in Highly Trained Youth Athletes: Echocardiographic Insights on Function and Adaptation.Journal of cardiovascular development and disease · 2022Review
- Independent effects of acute normobaric hypoxia and hypobaric hypoxia on human physiology.Scientific reports · 2022Article
- Does Hypoxia and Stress Erythropoiesis Compromise Cardiac Function in Healthy Adults? A Randomized Trial.Sports medicine - open · 2022Article
- A change of heart: Mechanisms of cardiac adaptation to acute and chronic hypoxia.The Journal of physiology · 2022Article
- Changes in cardiac function following a speed ascent to the top of Europe at 4808 m.European journal of applied physiology · 2022Article
- Altitude exposure in pediatric pulmonary hypertension-are we ready for (flight) recommendations?Cardiovascular diagnosis and therapy · 2021Review
- Myocardial adaptability in young and older-aged sea-level habitants sojourning at Mt Kilimanjaro: are cardiac compensatory limits reached in older trekkers?European journal of applied physiology · 2020Article
- PPARA genetic variants increase the risk for cardiac pumping function reductions following acute high-altitude exposure: A self-controlled study.Molecular genetics & genomic medicine · 2019Article
- Impairment of left atrial mechanics does not contribute to the reduction in stroke volume after active ascent to 4559 m.Scandinavian journal of medicine & science in sports · 2019Article
- The influence of adrenergic stimulation on sex differences in left ventricular twist mechanics.The Journal of physiology · 2017Article
- Heart-lung interaction in a model of COPD: importance of lung volume and direct ventricular interaction.American journal of physiology. Heart and circulatory physiology · 2016Article
- Hot and Hypoxic Environments Inhibit Simulated Soccer Performance and Exacerbate Performance Decrements When Combined.Frontiers in physiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Impaired myocardial systolic contraction and diastolic relaxation have been suggested as possible mechanisms contributing to the decreased stroke volume (SV) observed at high altitude (HA). To determine whether intrinsic myocardial performance is a limiting factor in the generation of SV at HA, we assessed left ventricular (LV) systolic and diastolic mechanics and volumes in 10 healthy participants (aged 32 ± 7; mean ± SD) at rest and during exercise at sea level (SL; 344 m) and after 10 days at 5,050 m. In contrast to SL, LV end-diastolic volume was ∼19% lower at rest (P = 0.004) and did not increase during exercise despite a greater untwisting velocity. Furthermore, resting SV was lower at HA (∼17%; 60 ± 10 vs. 70 ± 8 ml) despite higher LV twist (43%), apical rotation (115%), and circumferential strain (17%). With exercise at HA, the increase in SV was limited (12 vs. 22 ml at SL), and LV apical rotation failed to augment. For the first time, we have demonstrated that EDV does not increase upon exercise at high altitude despite enhanced in vivo diastolic relaxation. The increase in LV mechanics at rest may represent a mechanism by which SV is defended in the presence of a reduced EDV. However, likely because of the higher LV mechanics at rest, no further increase was observed up to 50% peak power. Consequently, although hypoxia does not suppress systolic function per se, the capacity to increase SV through greater deformation during submaximal exercise at HA is restricted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.