Trial reportPloS one2015
Resting state BOLD functional connectivity at 3T: spin echo versus gradient echo EPI.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Apparent Diffusion Coefficient fMRI shines light on white matter resting-state connectivity compared to BOLD.Communications biology · 2025Article
- Layer-specific BOLD effects in gradient and spin-echo acquisitions in somatosensory cortex.Magnetic resonance in medicine · 2025Article
- Hippocampus and olfactory impairment in Parkinson disease: a comparative exploratory combined volumetric/functional MRI study.Neuroradiology · 2024Article
- The restoring of interhemispheric brain connectivity following carotid endarterectomy: an exploratory observational study.Brain imaging and behavior · 2022Observational
- The mid-term effects of carotid endarterectomy on cognition and regional neural activity analyzed with the amplitude of low frequency fluctuations technique.Neuroradiology · 2022Observational
- The role of mid-insula in the relationship between cardiac interoceptive attention and anxiety: evidence from an fMRI study.Scientific reports · 2018Article
- Comparison of Resting-State Brain Activation Detected by BOLD, Blood Volume and Blood Flow.Frontiers in human neuroscience · 2018Article
- The Psychoactive Designer Drug and Bath Salt Constituent MDPV Causes Widespread Disruption of Brain Functional Connectivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Spin-Echo Resting-State Functional Connectivity in High-Susceptibility Regions: Accuracy, Reliability, and the Impact of Physiological Noise.Brain connectivity · 2016Article
- A Hitchhiker's Guide to Functional Magnetic Resonance Imaging.Frontiers in neuroscience · 2016Review
- Increased connectivity between sensorimotor and attentional areas in Parkinson's disease.Neuroradiology · 2015Article
- Do intuitive and deliberate judgments rely on two distinct neural systems? A case study in face processing.Frontiers in human neuroscience · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous evidence showed that, due to refocusing of static dephasing effects around large vessels, spin-echo (SE) BOLD signals offer an increased linearity and promptness with respect to gradient-echo (GE) acquisition, even at low field. These characteristics suggest that, despite the reduced sensitivity, SE fMRI might also provide a potential benefit when investigating spontaneous fluctuations of brain activity. However, there are no reports on the application of spin-echo fMRI for connectivity studies at low field. In this study we compared resting state functional connectivity as measured with GE and SE EPI sequences at 3T. Main results showed that, within subject, the GE sensitivity is overall larger with respect to that of SE, but to a less extent than previously reported for activation studies. Noteworthy, the reduced sensitivity of SE was counterbalanced by a reduced inter-subject variability, resulting in comparable group statistical connectivity maps for the two sequences. Furthermore, the SE method performed better in the ventral portion of the default mode network, a region affected by signal dropout in standard GE acquisition. Future studies should clarify if these features of the SE BOLD signal can be beneficial to distinguish subtle variations of functional connectivity across different populations and/or treatments when vascular confounds or regions affected by signal dropout can be a critical issue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.