Evidence map›Paper›PMID 25749188›Full record

ArticleExperimental neurology2015

Deferoxamine reduces intracerebral hemorrhage-induced white matter damage in aged rats.

Wei Ni, Masanobu Okauchi, Tetsuhiro Hatakeyama, Yuxiang Gu, Richard F Keep, Guohua Xi, Ya Hua

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 58 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. HDAC inhibition reduces white matter injury after intracerebral hemorrhage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  8. Article
  9. Review
  10. IL-4/STAT6 signaling facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  11. Article
  12. Article
  13. Article
  14. The MCBritish journal of pharmacology · 2019
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Neuroprotection of brain-permeable iron chelator VK-28 against intracerebral hemorrhage in mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Wei NiDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Masanobu OkauchiDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Tetsuhiro HatakeyamaDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Yuxiang GuDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Richard F KeepDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Guohua XiDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Ya HuaDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA. Electronic address: yahua@umich.edu.
University of Michigan–Ann Arbor · US

Funding

Deferoxamine therapy for intracerebral hemorrhageU01NS052510 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XI, GUOHUA · 2007 to 2010
$1.8M
Mechanisms of Brain Injury after Intraventricular HemorrhageR01NS073595 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XI, GUOHUA · 2012 to 2016
$1.7M
Mechanisms of early brain injury after subarachnoid hemmorrhageR01NS079157 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XI, GUOHUA · 2012 to 2016
$1.7M
Lipocalin-2 and Intracerebral Hemorrhage-induced Brain InjuryR21NS091545 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUA, YA · 2015 to 2016
$427k
CD47 and hematoma clearance in intracerebral hemorrhageR21NS084049 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUA, YA · 2013 to 2014
$425k
NINDS NIH HHS NS-052510,NINDS NIH HHS NS-073595NINDS NIH HHS NS-079157NINDS NIH HHS NS-084049NINDS NIH HHS NS-091545NINDS NIH HHS R01 NS073595NINDS NIH HHS R01 NS079157NINDS NIH HHS R21 NS084049NINDS NIH HHS R21 NS091545NINDS NIH HHS U01 NS052510
6 · The paper itself

Abstract

Iron contributes to c-Jun N-terminal kinases (JNK) activation in young rats and white matter injury in piglets after intracerebral hemorrhage (ICH). In the present study, we examined the effect of deferoxamine on ICH-induced white matter injury and JNK activation and in aged rats. Male Fischer 344 rats (18months old) had either an intracaudate injection of 100μl of autologous blood or a needle insertion (sham). The rats were treated with deferoxamine or vehicle with different regimen (dosage, duration and time window). White matter injury and activation of JNK were examined. We found that a dose of DFX should be at more than 10mg/kg for a therapeutic duration more than 2days with a therapeutic time window of 12h to reduce ICH-induced white matter loss at 2months. ICH-induced white matter injury was associated with JNK activation. The protein levels of phosphorylated-JNK (P-JNK) were upregulated at day-1 after ICH and then gradually decreased. P-JNK immunoreactivity was mostly located in white matter bundles. ICH-induced JNK activation was reduced by DFX treatment. This study demonstrated that DFX can reduce ICH-induced JNK activation and white matter damage.

Indexed as

AgingAnalysis of VarianceAnimalsCerebral HemorrhageDeferoxamineDisease Models, AnimalDose-Response Relationship, DrugFunctional LateralityLeukoencephalopathiesMaleMAP Kinase Kinase 4Myelin Basic ProteinRatsRats, Inbred F344SiderophoresTime FactorsDeferoxamineMAP Kinase Kinase 4Myelin Basic ProteinSiderophoresc-Jun N-terminal kinasesDeferoxamineIntracerebral hemorrhageWhite matter injury

Identifiers

PMID25749188
PMCPMC4668331
OpenAlexW1974502398

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.