Evidence map›Paper›PMID 25749155›Full record

ReviewBiochimica et biophysica acta2015

Bioelectrical regulation of cell cycle and the planarian model system.

Paul G Barghouth, Manish Thiruvalluvan, Néstor J Oviedo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochimica et biophysica acta, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Bioelectricity in dental medicine: a narrative review.Biomedical engineering online · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Paul G BarghouthDepartment of Molecular and Cell Biology, School of Natural Sciences, University of California at Merced, 5200 North Lake Road, Merced, CA 95343, USA; Quantitative and Systems Biology Graduate Program, University of California at Merced, 5200 North Lake Road, Merced, CA 95343, USA.
Manish ThiruvalluvanDepartment of Molecular and Cell Biology, School of Natural Sciences, University of California at Merced, 5200 North Lake Road, Merced, CA 95343, USA; Quantitative and Systems Biology Graduate Program, University of California at Merced, 5200 North Lake Road, Merced, CA 95343, USA.
Néstor J OviedoDepartment of Molecular and Cell Biology, School of Natural Sciences, University of California at Merced, 5200 North Lake Road, Merced, CA 95343, USA; Quantitative and Systems Biology Graduate Program, University of California at Merced, 5200 North Lake Road, Merced, CA 95343, USA; Health Sciences Research Institute, University of California at Merced, 5200 North Lake Road, Merced, CA 95343, USA. Electronic address: noviedo2@ucmerced.edu.
University of California, Merced · US

Funding

Molecular mechanisms controlling cell proliferation during tissue turnover and caR21CA176114 · NCI · UNIVERSITY OF CALIFORNIA, MERCED · PI OVIEDO, NESTOR J · 2014 to 2015
$361k
Genetic regulation of stem cell behavior in planariansR15GM109372 · NIGMS · UNIVERSITY OF CALIFORNIA, MERCED · PI OVIEDO, NESTOR J · 2014 to 2014
$352k
NCI NIH HHS CA176114NCI NIH HHS R21 CA176114NIGMS NIH HHS GM109372NIGMS NIH HHS R15 GM109372
6 · The paper itself

Abstract

Cell cycle regulation through the manipulation of endogenous membrane potentials offers tremendous opportunities to control cellular processes during tissue repair and cancer formation. However, the molecular mechanisms by which biophysical signals modulate the cell cycle remain underappreciated and poorly understood. Cells in complex organisms generate and maintain a constant voltage gradient across the plasma membrane known as the transmembrane potential. This potential, generated through the combined efforts of various ion transporters, pumps and channels, is known to drive a wide range of cellular processes such as cellular proliferation, migration and tissue regeneration while its deregulation can lead to tumorigenesis. These cellular regulatory events, coordinated by ionic flow, correspond to a new and exciting field termed molecular bioelectricity. We aim to present a brief discussion on the biophysical machinery involving membrane potential and the mechanisms mediating cell cycle progression and cancer transformation. Furthermore, we present the planarian Schmidtea mediterranea as a tractable model system for understanding principles behind molecular bioelectricity at both the cellular and organismal level. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers.

Indexed as

AnimalsCalciumCell CycleCell MovementCell ProliferationCell Transformation, NeoplasticChloridesHumansIon ChannelsIon TransportMembrane PotentialsModels, BiologicalNeoplasmsPlanariansSodiumCalciumChloridesIon ChannelsSodiumCancerCell cycleMembrane potentialPlanarianStem cell

Identifiers

PMID25749155
PMCPMC4561208
OpenAlexW2163523849

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.