ArticleOncotarget2015
A standardized autopsy procurement allows for the comprehensive study of DIPG biology.
Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01106794 (Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma), which is not on this map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma
Who cites it
30 citing papers in PubMed, 44 citations in OpenAlex.
- Leptomeningeal metastases from solid tumors: A Society for Neuro-Oncology and American Society of Clinical Oncology consensus review on clinical management and future directions.Neuro-oncology · 2024Review
- Research autopsy programmes in oncology: shared experience from 14 centres across the world.The Journal of pathology · 2024Article
- Rapid autopsies to enhance metastatic research: the UPTIDER post-mortem tissue donation program.NPJ breast cancer · 2024Article
- Patient-Derived Orthotopic Xenograft Models for High-Grade Pediatric Brain Cancers.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Pediatric Postmortem Tissue Donation in the Confines of a Pandemic: A Model of Collaboration.Pediatric neurology · 2023Article
- Review
- Overcoming barriers to establishing autopsy procurement programs in pediatric patients with central nervous system tumors: a call to develop regional centers.Journal of neuro-oncology · 2021Article
- Convection Enhanced Delivery for Diffuse Intrinsic Pontine Glioma: Review of a Single Institution Experience.Pharmaceutics · 2020Review
- Harmonization of postmortem donations for pediatric brain tumors and molecular characterization of diffuse midline gliomas.Scientific reports · 2020Article
- Toward a standard pathological and molecular characterization of recurrent glioma in adults: a Response Assessment in Neuro-Oncology effort.Neuro-oncology · 2020Review
- Clinical trials using molecular stratification of pediatric brain tumors.Translational pediatrics · 2020Review
- Increasing value of autopsies in patients with brain tumors in the molecular era.Journal of neuro-oncology · 2019Article
- Article
- Differential Expression of Wilms' Tumor Protein in Diffuse Intrinsic Pontine Glioma.Journal of neuropathology and experimental neurology · 2019Article
- Current Murine Models and New Developments in H3K27M Diffuse Midline Gliomas.Frontiers in oncology · 2019Article
- International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma.Journal of neuro-oncology · 2019Article
- Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2018Article
- Diffuse Intrinsic Pontine Glioma : Clinical Features, Molecular Genetics, and Novel Targeted Therapeutics.Journal of Korean Neurosurgical Society · 2018Review
- Rapid autopsy of a patient with recurrent anaplastic ependymoma.Palliative & supportive care · 2018Article
- Deceptive morphologic and epigenetic heterogeneity in diffuse intrinsic pontine glioma.Oncotarget · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Diffuse intrinsic pontine glioma (DIPG) is one of the least understood and most deadly childhood cancers. Historically, there has been a paucity of DIPG specimens for molecular analysis. However, due to the generous participation of DIPG families in programs for postmortem specimen donation, there has been a recent surge in molecular analysis of newly available tumor specimens. Collaborative efforts to share data and tumor specimens have resulted in rapid discoveries in other pediatric brain tumors, such as medulloblastoma, and therefore have the potential to shed light on the biology of DIPG. Given the generous gift of postmortem tissue donation from DIPG patients, there is a need for standardized postmortem specimen accrual to facilitate rapid and effective multi-institutional molecular studies.We developed and implemented an autopsy protocol for rapid procurement, documenting and storing these specimens. Sixteen autopsies were performed throughout the United States and Canada and processed using a standard protocol and inventory method, including specimen imaging, fixation, snap freezing, orthotopic injection, or preservation. This allowed for comparative clinical and biological studies of rare postmortem DIPG tissue specimens, generation of in vivo and in vitro models of DIPG, and detailed records to facilitate collaborative analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.