ArticleCell stem cell2015
Transient pairing of homologous Oct4 alleles accompanies the onset of embryonic stem cell differentiation.
Article in Cell stem cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- RID is required for both repeat-induced point mutation and nucleation of a novel transitional heterochromatic state for euchromatic repeats.Nucleic acids research · 2025Article
- Interchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiation.Nature communications · 2022Article
- Regulatory mechanisms ensuring coordinated expression of functionally related genes.Trends in genetics : TIG · 2022Review
- The 3D genome landscape: Diverse chromosomal interactions and their functional implications.Frontiers in cell and developmental biology · 2022Review
- Nuclear deformation guides chromatin reorganization in cardiac development and disease.Nature biomedical engineering · 2021Article
- Modulation of C-to-T mutation by recombination-independent pairing of closely positioned DNA repeats.Biophysical journal · 2021Article
- Recombination-independent recognition of DNA homology for meiotic silencing inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Engineering 3D genome organization.Nature reviews. Genetics · 2021Review
- Chromatin Regulation at Parental Gene Promoters by Pseudogene Sense lncRNAs.Methods in molecular biology (Clifton, N.J.) · 2021Article
- MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression.Nature communications · 2020Article
- Dynamical reorganization of the pluripotency transcription factors Oct4 and Sox2 during early differentiation of embryonic stem cells.Scientific reports · 2020Article
- Functions and properties of nuclear lncRNAs-from systematically mapping the interactomes of lncRNAs.Journal of biomedical science · 2020Review
- Interchromosomal interactions: A genomic love story of kissing chromosomes.The Journal of cell biology · 2019Review
- The Role of RNA Polymerase II Contiguity and Long-Range Interactions in the Regulation of Gene Expression in Human Pluripotent Stem Cells.Stem cells international · 2019Article
- Developing novel methods to image and visualize 3D genomes.Cell biology and toxicology · 2018Review
- Partition of Repeat-Induced Point Mutations Reveals Structural Aspects of Homologous DNA-DNA Pairing.Biophysical journal · 2018Article
- Regenerative Medicine Strategies in Biomedical Implants.Current osteoporosis reports · 2018Review
- Nuclear Architecture in the Nervous System: Development, Function, and Neurodevelopmental Diseases.Frontiers in genetics · 2018Review
- A tetrad of chromatin interactions for chromosome pairing in X inactivation.Nature structural & molecular biology · 2017Article
- PAR-TERRA directs homologous sex chromosome pairing.Nature structural & molecular biology · 2017Article
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5 authors.
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Abstract
The relationship between chromatin organization and transcriptional regulation is an area of intense investigation. We characterized the spatial relationships between alleles of the Oct4, Sox2, and Nanog genes in single cells during the earliest stages of mouse embryonic stem cell (ESC) differentiation and during embryonic development. We describe homologous pairing of the Oct4 alleles during ESC differentiation and embryogenesis, and we present evidence that pairing is correlated with the kinetics of ESC differentiation. Importantly, we identify critical DNA elements within the Oct4 promoter/enhancer region that mediate pairing of Oct4 alleles. Finally, we show that mutation of OCT4/SOX2 binding sites within this region abolishes inter-chromosomal interactions and affects accumulation of the repressive H3K9me2 modification at the Oct4 enhancer. Our findings demonstrate that chromatin organization and transcriptional programs are intimately connected in ESCs and that the dynamic positioning of the Oct4 alleles is associated with the transition from pluripotency to lineage specification.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.