Evidence map›Paper›PMID 25748884›Full record

ArticlePsychiatry research2015

Disrupted fornix integrity in children with chromosome 22q11.2 deletion syndrome.

Yi Deng, Naomi J Goodrich-Hunsaker, Margarita Cabaral, David G Amaral, Michael H Buonocore, Danielle Harvey, Kristopher Kalish, Owen T Carmichael, Cynthia M Schumann, Aaron Lee and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. DWI Hyperintensity in the Fornix Fimbria on MRI in Children.AJNR. American journal of neuroradiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Yi DengDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, CA 95817, USA; The MIND Institute, University of California, Davis, Sacramento, CA 95817, USA.
Naomi J Goodrich-HunsakerDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, CA 95817, USA; The MIND Institute, University of California, Davis, Sacramento, CA 95817, USA.
Margarita CabaralDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, CA 95817, USA; The MIND Institute, University of California, Davis, Sacramento, CA 95817, USA.
David G AmaralDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, CA 95817, USA; The MIND Institute, University of California, Davis, Sacramento, CA 95817, USA.
Michael H BuonocoreDepartment of Radiology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.
Danielle HarveyDivision of Biostatistics, Department of Public Health Sciences, University of California, Davis, CA 95616, USA.
Kristopher KalishGraduate Group in Computer Science, University of California, Davis, CA 95616, USA.
Owen T CarmichaelGraduate Group in Computer Science, University of California, Davis, CA 95616, USA; Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.
Cynthia M SchumannDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, CA 95817, USA; The MIND Institute, University of California, Davis, Sacramento, CA 95817, USA.
Aaron LeeDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, CA 95817, USA; The MIND Institute, University of California, Davis, Sacramento, CA 95817, USA.
Robert F DoughertyDepartment of Psychology, Stanford University, Stanford, CA 94305, USA.
Lee M PerryDepartment of Psychology, Stanford University, Stanford, CA 94305, USA.
Brian A WandellDepartment of Psychology, Stanford University, Stanford, CA 94305, USA.
Tony J SimonDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, CA 95817, USA; The MIND Institute, University of California, Davis, Sacramento, CA 95817, USA. Electronic address: tjsimon@ucdavis.edu.
University of California, Davis · USStanford University · US

Funding

Visuospatial Cognitive Deficit in Del22q11.2 SyndromeR01HD042974 · NICHD · UNIVERSITY OF CALIFORNIA DAVIS · PI SIMON, TONY J · 2003 to 2013
$4.9M
"MR Morphometrics and Cognitive Decline Rate in Large-Scale Aging Studies"K01AG030514 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CARMICHAEL, OWEN T. · 2008 to 2012
$495k
NIA NIH HHS AG030514NIA NIH HHS K01 AG030514NICHD NIH HHS R01 HD042974NICHD NIH HHS R01HD042974
6 · The paper itself

Abstract

The fornix is the primary subcortical output fiber system of the hippocampal formation. In children with 22q11.2 deletion syndrome (22q11.2DS), hippocampal volume reduction has been commonly reported, but few studies as yet have evaluated the integrity of the fornix. Therefore, we investigated the fornix of 45 school-aged children with 22q11.2DS and 38 matched typically developing (TD) children. Probabilistic diffusion tensor imaging (DTI) tractography was used to reconstruct the body of the fornix in each child׳s brain native space. Compared with children, significantly lower fractional anisotropy (FA) and higher radial diffusivity (RD) was observed bilaterally in the body of the fornix in children with 22q11.2DS. Irregularities were especially prominent in the posterior aspect of the fornix where it emerges from the hippocampus. Smaller volumes of the hippocampal formations were also found in the 22q11.2DS group. The reduced hippocampal volumes were correlated with lower fornix FA and higher fornix RD in the right hemisphere. Our findings provide neuroanatomical evidence of disrupted hippocampal connectivity in children with 22q11.2DS, which may help to further understand the biological basis of spatial impairments, affective regulation, and other factors related to the ultra-high risk for schizophrenia in this population.

Indexed as

AdolescentAnisotropyChildDiffusion Tensor ImagingDiGeorge SyndromeFemaleFornix, BrainHippocampusHumansMaleOrgan SizeSchizophreniaChromosome 22q11.2 deletionConnectivityHippocampal formationTractographyVelo-cardio-facial Syndrome

Identifiers

PMID25748884
PMCPMC4404209
OpenAlexW2036728827

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.