Evidence map›Paper›PMID 25748771›Full record

ReviewJournal of the American Board of Family Medicine : JABFM

Diagnosis and management of acute coronary syndrome: an evidence-based update.

Jennifer N Smith, Jenna M Negrelli, Megha B Manek, Emily M Hawes, Anthony J Viera

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Journal of the American Board of Family Medicine : JABFM. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT04661709. Cited by 58 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04661709 phase4unknown status

Efficacy and Safety of Chinese Herbal Medicine Wen Xin Granules for the Treatment of Unstable Angina Pectoris With Yang Deficiency and Blood Stasis Syndrome: Study Protocol for a Randomized Controlled Trial

Ran2021Enrolled502Registered outcomes4Posted comparisons0ConditionsChinese Herbal Medicine, Coronary Heart Disease, Unstable AnginaArmsAspirin Enteric-coated Tablets, Atorvastatin calcium, Clopidogrel Hydrogen Sulfate 75 MG Oral Tablet, glyceryl trinitrate, Isosorbide Mononitrate Tab 20 MG
Open the trial in the graph
NCT05335629 nacompleted

Evaluation of the Effect of Dapagliflozin on Cardiac Remodeling in Post Myocardial Infarction Patients

Ran2022Enrolled54Registered outcomes2Posted comparisons0ConditionsDiabetes Mellitus, Type 2, Myocardial Infarction, Myocardial Remodeling, VentricularArmsDapagliflozin 10mg Tab
Open the trial in the graph
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  13. Cognition and coronary events: A narrative overview of neurocognitive impairment in ACS patients.American heart journal plus : cardiology research and practice · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jennifer N SmithFrom the Department of Pharmacy, University of North Carolina Medical Center, Chapel Hill, NC (JNS, JMN, EMH); Department of Family Medicine, Guthrie/Robert Packer Hospital, Sayre, PA (MBM); Department of Family Medicine, University of North Carolina School of Medicine, Chapel Hill, NC (EMH, AJV) j.smith@usciences.edu.
Jenna M NegrelliFrom the Department of Pharmacy, University of North Carolina Medical Center, Chapel Hill, NC (JNS, JMN, EMH); Department of Family Medicine, Guthrie/Robert Packer Hospital, Sayre, PA (MBM); Department of Family Medicine, University of North Carolina School of Medicine, Chapel Hill, NC (EMH, AJV).
Megha B ManekFrom the Department of Pharmacy, University of North Carolina Medical Center, Chapel Hill, NC (JNS, JMN, EMH); Department of Family Medicine, Guthrie/Robert Packer Hospital, Sayre, PA (MBM); Department of Family Medicine, University of North Carolina School of Medicine, Chapel Hill, NC (EMH, AJV).
Emily M HawesFrom the Department of Pharmacy, University of North Carolina Medical Center, Chapel Hill, NC (JNS, JMN, EMH); Department of Family Medicine, Guthrie/Robert Packer Hospital, Sayre, PA (MBM); Department of Family Medicine, University of North Carolina School of Medicine, Chapel Hill, NC (EMH, AJV).
Anthony J VieraFrom the Department of Pharmacy, University of North Carolina Medical Center, Chapel Hill, NC (JNS, JMN, EMH); Department of Family Medicine, Guthrie/Robert Packer Hospital, Sayre, PA (MBM); Department of Family Medicine, University of North Carolina School of Medicine, Chapel Hill, NC (EMH, AJV).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute coronary syndrome (ACS) describes the range of myocardial ischemic states that includes unstable angina, non-ST elevated myocardial infarction (MI), or ST-elevated MI. ACS is associated with substantial morbidity and mortality and places a large financial burden on the health care system. The diagnosis of ACS begins with a thorough clinical assessment of a patient's presenting symptoms, electrocardiogram, and cardiac troponin levels as well as a review of past medical history. Early risk stratification can assist clinicians in determining whether an early invasive management strategy or an initial conservative strategy should be pursued and can help determine appropriate pharmacologic therapies. Key components in the management of ACS include coronary revascularization when indicated; prompt initiation of dual antiplatelet therapy and anticoagulation; and consideration of adjuvant agents including β blockers, inhibitors of the renin angiotensin system, and HmG-coenzyme A reductase inhibitors. It is essential for clinicians to take an individualized approach to treatment and consider long-term safety and efficacy when managing patients with a history of ACS after hospital discharge.

Indexed as

Disease ManagementAcute Coronary SyndromeEvidence-Based MedicineHumansAcute Coronary SyndromeCardiologyMyocardial Infarction

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.