ArticleThe Korean journal of parasitology2015
Antileishmanial and cytotoxic effects of essential oil and methanolic extract of Myrtus communis L.
Article in The Korean journal of parasitology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of Curcumin and its Derivatives as Valuable Sources of Antileishmanial Agents.Acta parasitologica · 2021Pooled it
- Article
- Antibacterial activity ofFrontiers in plant science · 2025Article
- Article
- The therapeutic value of Myrtus communis L.: an updated review.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Synergistic antileishmanial activity of erythrodiol, uvaol, and oleanolic acid isolated from olive leaves of3 Biotech · 2023Article
- How to Naturally Support the Immune System in Inflammation-Essential Oils as Immune Boosters.Biomedicines · 2023Review
- Leishmanicidal and immunomodulatory activities of the formononetin (a natural isoflavone) against Leishmania tropica.BMC research notes · 2023Article
- Essential Oils in the Treatment of Various Types of Acne-A Review.Plants (Basel, Switzerland) · 2022Review
- Chemical composition, antileishmanial, and cytotoxic effectsParasite epidemiology and control · 2022Article
- Botanic Garden as a Factory of Molecules:Plants (Basel, Switzerland) · 2022Article
- HAS 1: A natural product from soil-isolatedFrontiers in pharmacology · 2022Article
- A nanoemulsion-based nanogel ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Article
- Cytotoxic and Antileishmanial Effects of Various Extracts ofTurkish journal of pharmaceutical sciences · 2021Article
- Article
- The potential role and apoptotic profile of three medicinal plant extracts onParasite epidemiology and control · 2021Article
- Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses.Oxidative medicine and cellular longevity · 2019Review
- Antioxidant Activity ofMedicines (Basel, Switzerland) · 2018Review
- Development, physicochemical characterization, and antimicrobial evaluation of niosomal myrtle essential oil.Research in pharmaceutical sciences · 2018Article
- Leishmanicidal Activity of Biogenic Fe₃O₄ Nanoparticles.Scientia pharmaceutica · 2017Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants used for traditional medicine contain a wide range of substances that can be used to treat various diseases such as infectious diseases. The present study was designed to evaluate the antileishmanial effects of the essential oil and methanolic extract of Myrtus communis against Leishmania tropica on an in vitro model. Antileishmanial effects of essential oil and methanolic extract of M. communis on promastigote forms and their cytotoxic activities against J774 cells were evaluated using MTT assay for 72 hr. In addition, their leishmanicidal activity against amastigote forms was determined in a macrophage model, for 72 hr. Findings showed that the main components of essential oil were α-pinene (24.7%), 1,8-cineole (19.6%), and linalool (12.6%). Findings demonstrated that M. communis, particularly its essential oil, significantly (P<0.05) inhibited the growth rate of promastigote and amastigote forms of L. tropica based on a dose-dependent response. The IC50 values for essential oil and methanolic extract was 8.4 and 28.9 μg/ml against promastigotes, respectively. These values were 11.6 and 40.8 μg/ml against amastigote forms, respectively. Glucantime as control drug also revealed IC50 values of 88.3 and 44.6 μg/ml for promastigotes and amastigotes of L. tropica, respectively. The in vitro assay demonstrated no significant cytotoxicity in J774 cells. However, essential oil indicated a more cytotoxic effect as compared with the methanolic extract of M. communis. The findings of the present study demonstrated that M. communis might be a natural source for production of a new leishmanicidal agent.
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