ArticleEnvironmental health perspectives2015
Analysis of Environmental Chemical Mixtures and Non-Hodgkin Lymphoma Risk in the NCI-SEER NHL Study.
Article in Environmental health perspectives, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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85 citing papers in PubMed.
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- Associations between Maternal Urinary Metabolite Concentrations of Selected Volatile Organic Compounds and Child Neurocognitive Development at Two Years of Age.Environmental health perspectives · 2025Article
- Partial Effects in Environmental Mixtures: Evidence and Guidance on Methods and Implications.Environmental health perspectives · 2025Article
- Frequentist Grouped Weighted Quantile Sum Regression for Correlated Chemical Mixtures.Statistics in medicine · 2025Article
- Association between Urinary Phenols and Parabens as Well as Breast Cancer.Iranian journal of public health · 2025Article
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- The associations between volatile organic compounds exposure and urine flow rate in US adults: NHANES 2011-2020.American journal of clinical and experimental urology · 2025Article
- Quantile regression based method for characterizing risk-specific behavioral patterns in relation to longitudinal left-censored biomarker data collected from heterogeneous populations.Journal of applied statistics · 2025Article
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- Prenatal exposure to multiple environmental chemicals and birth size.Journal of exposure science & environmental epidemiology · 2024Article
- Assessing the Risk of Heart Attack: A Bayesian Kernel Machine Regression Analysis of Heavy Metal Mixtures.Research square · 2024Article
25 more citing papers are in PubMed but not listed here.
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9 authors.
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Abstract
backgroundThere are several suspected environmental risk factors for non-Hodgkin lymphoma (NHL). The associations between NHL and environmental chemical exposures have typically been evaluated for individual chemicals (i.e., one-by-one).
objectivesWe determined the association between a mixture of 27 correlated chemicals measured in house dust and NHL risk.
methodsWe conducted a population-based case-control study of NHL in four National Cancer Institute-Surveillance, Epidemiology, and End Results centers--Detroit, Michigan; Iowa; Los Angeles County, California; and Seattle, Washington--from 1998 to 2000. We used weighted quantile sum (WQS) regression to model the association of a mixture of chemicals and risk of NHL. The WQS index was a sum of weighted quartiles for 5 polychlorinated biphenyls (PCBs), 7 polycyclic aromatic hydrocarbons (PAHs), and 15 pesticides. We estimated chemical mixture weights and effects for study sites combined and for each site individually, and also for histologic subtypes of NHL.
resultsThe WQS index was statistically significantly associated with NHL overall [odds ratio (OR) = 1.30; 95% CI: 1.08, 1.56; p = 0.006; for one quartile increase] and in the study sites of Detroit (OR = 1.71; 95% CI: 1.02, 2.92; p = 0.045), Los Angeles (OR = 1.44; 95% CI: 1.00, 2.08; p = 0.049), and Iowa (OR = 1.76; 95% CI: 1.23, 2.53; p = 0.002). The index was marginally statistically significant in Seattle (OR = 1.39; 95% CI: 0.97, 1.99; p = 0.071). The most highly weighted chemicals for predicting risk overall were PCB congener 180 and propoxur. Highly weighted chemicals varied by study site; PCBs were more highly weighted in Detroit, and pesticides were more highly weighted in Iowa.
conclusionsAn index of chemical mixtures was significantly associated with NHL. Our results show the importance of evaluating chemical mixtures when studying cancer risk.
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