ArticlePLoS genetics2015
Drosophila S6 Kinase like inhibits neuromuscular junction growth by downregulating the BMP receptor thickveins.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- A rare recurring gain-of-function variant in BMPR2 causes neurodevelopmental phenotypes in humans and flies.American journal of human genetics · 2026Article
- Review
- Drosophila Atlastin regulates synaptic vesicle mobilization independent of bone morphogenetic protein signaling.Biological research · 2023Article
- Gbb glutathionylation promotes its proteasome-mediated degradation to inhibit synapse growth.The Journal of cell biology · 2023Article
- Local BMP signaling: A sensor for synaptic activity that balances synapse growth and function.Current topics in developmental biology · 2022Review
- Glia-derived temporal signals orchestrate neurogenesis in theProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Ttm50 facilitates calpain activation by anchoring it to calcium stores and increasing its sensitivity to calcium.Cell research · 2021Article
- Target-dependent retrograde signaling mediates synaptic plasticity at the Drosophila neuromuscular junction.Developmental neurobiology · 2019Article
- AWD regulates timed activation of BMP signaling in intestinal stem cells to maintain tissue homeostasis.Nature communications · 2019Article
- Calcium-Activated Calpain Specifically Cleaves Glutamate Receptor IIA But Not IIB at theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The autophagy-related geneThe Journal of biological chemistry · 2019Article
- Tao Negatively Regulates BMP Signaling During Neuromuscular Junction Development in Drosophila.Developmental neurobiology · 2019Article
- BMP signaling downstream of the Highwire E3 ligase sensitizes nociceptors.PLoS genetics · 2018Article
- Neurexin-Neuroligin 1 regulates synaptic morphology and functions via the WAVE regulatory complex ineLife · 2018Article
- The Rap activator Gef26 regulates synaptic growth and neuronal survival via inhibition of BMP signaling.Molecular brain · 2017Article
- Neuroligin 4 regulates synaptic growth via the bone morphogenetic protein (BMP) signaling pathway at theThe Journal of biological chemistry · 2017Article
- MAN1 Restricts BMP Signaling During Synaptic Growth in Drosophila.Cellular and molecular neurobiology · 2017Article
- Secreted tissue inhibitor of matrix metalloproteinase restrictsJournal of cell science · 2017Article
- Presynaptic morphogenesis, active zone organization and structural plasticity in Drosophila.Current opinion in neurobiology · 2017Review
- Angelman Syndrome Protein Ube3a Regulates Synaptic Growth and Endocytosis by Inhibiting BMP Signaling in Drosophila.PLoS genetics · 2016Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Synaptic connections must be precisely controlled to ensure proper neural circuit formation. In Drosophila melanogaster, bone morphogenetic protein (BMP) promotes growth of the neuromuscular junction (NMJ) by binding and activating the BMP ligand receptors wishful thinking (Wit) and thickveins (Tkv) expressed in motor neurons. We report here that an evolutionally conserved, previously uncharacterized member of the S6 kinase (S6K) family S6K like (S6KL) acts as a negative regulator of BMP signaling. S6KL null mutants were viable and fertile but exhibited more satellite boutons, fewer and larger synaptic vesicles, larger spontaneous miniature excitatory junctional potential (mEJP) amplitudes, and reduced synaptic endocytosis at the NMJ terminals. Reducing the gene dose by half of tkv in S6KL mutant background reversed the NMJ overgrowth phenotype. The NMJ phenotypes of S6KL mutants were accompanied by an elevated level of Tkv protein and phosphorylated Mad, an effector of the BMP signaling pathway, in the nervous system. In addition, Tkv physically interacted with S6KL in cultured S2 cells. Furthermore, knockdown of S6KL enhanced Tkv expression, while S6KL overexpression downregulated Tkv in cultured S2 cells. This latter effect was blocked by the proteasome inhibitor MG132. Our results together demonstrate for the first time that S6KL regulates synaptic development and function by facilitating proteasomal degradation of the BMP receptor Tkv.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.