ArticleLymphatic research and biology2015
Intermittent Pneumatic Compression Enhances Formation of Edema Tissue Fluid Channels in Lymphedema of Lower Limbs.
Article in Lymphatic research and biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Intermittent pneumatic compression devices for the prevention and treatment of breast cancer-related lymphedema-a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Pooled it
- [S1 guideline on intermittent pneumatic compression (IPC)].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2018Guideline
- Enhancing Diagnostic Precision and Treatment Effectiveness Using Indocyanine Green Lymphography in Lymphedema.Annals of rehabilitation medicine · 2026Article
- Patient-specific numerical simulation of compression therapy effects on interstitial fluid motion in lower limb lymphedema.Biomechanics and modeling in mechanobiology · 2025Article
- The effect of compression therapies and therapeutic modalities on lymphedema secondary to cancer: a rapid review and evidence map.Medical oncology (Northwood, London, England) · 2024Review
- Therapist versus Machine-Immediate Effects of Manual versus Mechanical Lymphatic Drainage in Patients with Secondary Lymphedema.Journal of clinical medicine · 2024Article
- A novel air microfluidics-enabled soft robotic sleeve: Toward realizing innovative lymphedema treatment.Biomicrofluidics · 2022Article
- From histo-anatomy to sonography in lymphedema: EURO-MUSCULUS/USPRM approach.European journal of physical and rehabilitation medicine · 2022Article
- Development and Themes of Diagnostic and Treatment Procedures for Secondary Leg Lymphedema in Patients with Gynecologic Cancers.Healthcare (Basel, Switzerland) · 2019Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn lymphedema, tissue fluid steadily accumulates in the subcutaneous space containing loose connective tissue. We documented previously that deformation of the structure of subcutaneous collagen bundles and fat by excess fluid leads to formation of "lakes" and interconnected channels with irregular shape. Since there is no force that could mobilize and propel stagnant fluid to the regions where lymphatics absorb and contract, this task should be taken over by external massage. The most effective in this respect seems to be the sequential intermittent pneumatic compression (IPC).
aimThe aim of the study was to observe whether IPC would enhance and accelerate formation of tissue fluid channels.
methodsTogether with the Biocompression Systems (Moonachie, NJ), we designed a high pressure intermittent compression device and used in it our therapy protocol for patients with obstructive lymphedema of lower limbs. The study was carried out on 18 patients with lymphedema stages II-IV. The IPC was applied daily for 1-2 hours. The follow up time was 24-36 months. Lymphoscintigraphy and immunohistopathology of tissue biopsies were used for evaluation of channel formation process.
resultsThe forced fluid flow brought about increase of the area of fluid channels in the thigh and groin, with a decrease in the calf. Concomitantly, with decrease of channel area in the calf, there was a decrease of calf circumference. No new lymphatic collectors were observed.
conclusionsCompression of limb lymphedema tissues leads to formation of tissue channels as pathways for evacuation of edema fluid.
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