ArticleThe Journal of allergy and clinical immunology2015
Insulin resistance, metabolic syndrome, and lung function in US adolescents with and without asthma.
Article in The Journal of allergy and clinical immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 1 of them a synthesis that pooled it.
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Who cites it
118 citing papers in PubMed, 1 synthesis or guideline pooled it, 177 citations in OpenAlex.
- Association between soft drinks consumption and asthma: a systematic review and meta-analysis.BMJ open · 2019Pooled it
- Asthma and high-intensity interval training have no effect on clustered cardiometabolic risk or arterial stiffness in adolescents.European journal of applied physiology · 2021Trial
- Association of lung function with functional limitation in older adults: A cross-sectional study.PloS one · 2021Trial
- Obesity-Related Asthma: Structure and Inflammation.Current allergy and asthma reports · 2026Review
- Association of triglyceride-glucose index with presence and development of impaired spirometry: results from Austrian LEAD cohort.BMC pulmonary medicine · 2026Article
- Type 2 Diabetes and the Lung - Cause and Consequence.Current diabetes reports · 2026Review
- A Short-Term High-Sugar Diet Induces Glucose Intolerance, Visceral Adipose Tissue Inflammation, and Exacerbates Experimental Allergic Asthma.Nutrients · 2026Article
- Phenotypic characterization of treatment-naïve childhood asthma with obesity: features of lung function, inflammation, and lipid profiles.European journal of pediatrics · 2026Article
- Assessment of ventilation distribution in overweight and obese children with asthma using electric impedance tomography: a cross-sectional study.Italian journal of pediatrics · 2026Article
- Hyperglycemia, receptor for advanced glycation end products, and small airways dysfunction in asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Article
- Low socioeconomic status, insulin resistance, asthma, and depression: A syndemic framework in Brazilian adolescents.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Dietary and lifestyle oxidative balance, metabolic dysfunction, and preserved ratio impaired spirometry in Chinese adults: a hospital-based cross-sectional study.Frontiers in nutrition · 2026Article
- Metformin use is associated with reduced systemic steroid courses among pediatric asthma patients with diabetes or elevated blood glucose levels.Respiratory medicine · 2025 · on this mapObservational
- The joint effect of triglyceride-glucose index and C-reactive protein levels on the risk of chronic obstructive pulmonary disease: a prospective cohort study.Lipids in health and disease · 2025Article
- Effects of metabolic syndrome and its components on pulmonary function and functional capacity in children and adolescents with obesity.European journal of pediatrics · 2025Article
- Asthma diagnosis is not associated with reduced beta-cell function in children and adolescents with obesity.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Article
- Impact of Insulin Concentrations and Insulin Resistance on Lung Function and Morbidity in Asthma.CHEST pulmonary · 2025Article
- Metformin effects on respiratory and metabolic outcomes in asthma and metabolic syndrome: a double-blind, randomized, placebo-controlled clinical trial.Annals of medicine and surgery (2012) · 2025Article
- Hospitalization Outcomes of Patients with Asthma, COPD, and Asthma-COPD Overlap Syndrome.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2025Article
- Blood Glucose Levels, Inflammation, and Mortality in Asthmatic Populations: A Prospective Cohort Study.Journal of epidemiology and global health · 2025Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundObesity increases both the risk of asthma and asthma severity and is a well-known risk factor for insulin resistance and the metabolic syndrome (MS) in children and adolescents.
objectiveWe aimed to examine the association among obesity, insulin sensitivity, MS, and lung function in US adolescents with and without asthma.
methodsWe performed a cross-sectional study of 1429 adolescents aged 12 to 17 years in the 2007-2010 National Health and Nutrition Examination Survey. Adjusted regression was used to assess the relationships among obesity, insulin sensitivity/resistance, MS, and lung function in children with and without asthma.
resultsInsulin resistance was negatively associated with FEV1 and forced vital capacity (FVC) in adolescents with and without asthma, whereas MS was associated with lower FEV1/FVC ratios, with a more pronounced decrease found among asthmatic patients; these associations were driven by overweight/obese adolescents. Higher body mass index was associated with a decrease in FEV1/FVC ratios among adolescents with insulin resistance. Compared with healthy participants, adolescents with MS had an approximately 2% decrease in FEV1/FVC ratios, adolescents with asthma had an approximately 6% decrease, and those with MS and asthma had approximately 10% decreased FEV1/FVC ratios (P < .05).
conclusionInsulin resistance and MS are associated with worsened lung function in overweight/obese adolescents. Asthma and MS synergistically decrease lung function, as do obesity and insulin resistance. These factors might contribute to the pathogenesis of asthma severity in obese patients and warrant further investigation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.