Evidence map›Paper›PMID 25747961›Full record

ReviewPharmacological research2015

Type 1 diabetes and gut microbiota: Friend or foe?

Changyun Hu, F Susan Wong, Li Wen

Abstract readReview
In one paragraph

Review in Pharmacological research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 56 citations in OpenAlex.

  1. Type 1 Diabetes Mellitus and Vitamin D.International journal of molecular sciences · 2025
    Review
  2. Microbiome Changes in Pregnancy Disorders.Antioxidants (Basel, Switzerland) · 2023
    Review
  3. Article
  4. Host gene effects on gut microbiota in type 1 diabetes.Biochemical Society transactions · 2022
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Oral Administration of BacterialOxidative medicine and cellular longevity · 2022
    Article
  10. The Genetics of Diabetes: What We Can Learn fromInternational journal of molecular sciences · 2021
    Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Targeting Glycoproteins as a therapeutic strategy for diabetes mellitus and its complications.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2020
    Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Changyun HuSection of Endocrinology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
F Susan WongInstitute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Cardiff, UK.
Li WenSection of Endocrinology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA. Electronic address: li.wen@yale.edu.
Yale University · USCardiff University · GB

Funding

Role of TLR9 in Beta Cell Function and DiabetesR01DK092882 · NIDDK · YALE UNIVERSITY · PI WEN, LI · 2012 to 2016
$1.8M
Dendritic cells in immuno-metabolic disorder in mouse and manR01DK100500 · NIDDK · YALE UNIVERSITY · PI WEN, LI · 2014 to 2017
$1.4M
Environment, innate immunity and type 1 diabetesR01DK088181 · NIDDK · YALE UNIVERSITY · PI WEN, LI · 2010 to 2013
$1.4M
NIDDK NIH HHS DK-088181NIDDK NIH HHS DK092882NIDDK NIH HHS R01 DK088181NIDDK NIH HHS R01 DK092882NIDDK NIH HHS R01 DK100500
6 · The paper itself

Abstract

Type 1 diabetes is a T cell-mediated autoimmune disease. Environmental factors play an important role in the initiation of the disease in genetically predisposed individuals. With the improved control of infectious disease, the incidence of autoimmune diseases, particularly type 1 diabetes, has dramatically increased in developed countries. Increasing evidence suggests that gut microbiota are involved in the pathogenesis of type 1 diabetes. Here we focus on recent advances in this field and provide a rationale for novel therapeutic strategies targeting gut microbiota for the prevention of type 1 diabetes.

Indexed as

AnimalsDiabetes Mellitus, Type 1Gastrointestinal MicrobiomeGastrointestinal TractHumansMice, Inbred NODAutoimmunityGut microbiotaNOD miceType 1 diabetes

Identifiers

PMID25747961
PMCPMC4469505
OpenAlexW1995591671

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.