ArticleThe Plant cell2015
ENHANCED DISEASE RESISTANCE4 associates with CLATHRIN HEAVY CHAIN2 and modulates plant immunity by regulating relocation of EDR1 in Arabidopsis.
Article in The Plant cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
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- Genetic variations associated with adaptation in Acrocomia palms: A comparative study across the Neotropics for crop improvement.PloS one · 2025Article
- Development of cleaved amplified polymorphic sequence marker for powdery mildew resistance in Korean malting barley using QTL-seq.Frontiers in plant science · 2025Article
- Uptake of oomycete RXLR effectors into host cells by clathrin-mediated endocytosis.The Plant cell · 2023Article
- Engineering plant immune circuit: walking to the bright future with a novel toolbox.Plant biotechnology journal · 2023Review
- Liguleless narrow and narrow odd dwarf act in overlapping pathways to regulate maize development and metabolism.The Plant journal : for cell and molecular biology · 2022Article
- CORK1, A LRR-Malectin Receptor Kinase, Is Required for Cellooligomer-Induced Responses inCells · 2022Article
- Microscopic and Transcriptomic Comparison of Powdery Mildew Resistance in the Progenies ofInternational journal of molecular sciences · 2022Article
- TuRLK1, a leucine-rich repeat receptor-like kinase, is indispensable for stripe rust resistance of YrU1 and confers broad resistance to multiple pathogens.BMC plant biology · 2022Article
- BRASSINOSTEROID-SIGNALING KINASE1 modulates MAP KINASE15 phosphorylation to confer powdery mildew resistance in Arabidopsis.The Plant cell · 2022Article
- ThePlant direct · 2022Article
- Study of natural diversity in response to a key pathogenicity regulator of Ralstonia solanacearum reveals new susceptibility genes in Arabidopsis thaliana.Molecular plant pathology · 2022Article
- A NAC Transcription Factor TuNAC69 Contributes to ANK-NLR-WRKY NLR-Mediated Stripe Rust Resistance in the Diploid WheatInternational journal of molecular sciences · 2022Article
- Novel Genomic Regions Linked toFrontiers in plant science · 2022Article
- Transcriptomic Analysis Reveals Candidate Genes Responding Maize Gray Leaf Spot Caused byPlants (Basel, Switzerland) · 2021Article
- SUSA2 is an F-box protein required for autoimmunity mediated by paired NLRs SOC3-CHS1 and SOC3-TN2.Nature communications · 2020Article
- Comparative transcriptome analysis between a resistant and a susceptible Chinese cabbage in response toPlant signaling & behavior · 2020Article
- Characterization of Pingliang xiaoheidou (ZDD 11047), a soybean variety with resistance to soybean cyst nematode Heterodera glycines.Plant molecular biology · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obligate biotrophs, such as the powdery mildew pathogens, deliver effectors to the host cell and obtain nutrients from the infection site. The interface between the plant host and the biotrophic pathogen thus represents a major battleground for plant-pathogen interactions. Increasing evidence shows that cellular trafficking plays an important role in plant immunity. Here, we report that Arabidopsis thaliana ENHANCED DISEASE RESISTANCE4 (EDR4) plays a negative role in resistance to powdery mildew and that the enhanced disease resistance in edr4 mutants requires salicylic acid signaling. EDR4 mainly localizes to the plasma membrane and endosomal compartments. Genetic analyses show that EDR4 and EDR1 function in the same genetic pathway. EDR1 and EDR4 accumulate at the penetration site of powdery mildew infection, and EDR4 physically interacts with EDR1, recruiting EDR1 to the fungal penetration site. In addition, EDR4 interacts with CLATHRIN HEAVY CHAIN2 (CHC2), and edr4 mutants show reduced endocytosis rates. Taken together, our data indicate that EDR4 associates with CHC2 and modulates plant immunity by regulating the relocation of EDR1 in Arabidopsis.
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