Evidence map›Paper›PMID 25747743›Full record

ArticleBrain, behavior, and immunity2015

Progenitor cells are mobilized by acute psychological stress but not beta-adrenergic receptor agonist infusion.

Natalie E Riddell, Victoria E Burns, Graham R Wallace, Kate M Edwards, Mark Drayson, Laura S Redwine, Suzi Hong, Jack C Bui, Johannes C Fischer, Paul J Mills and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Mobilizing Immune Cells With Exercise for Cancer Immunotherapy.Exercise and sport sciences reviews · 2017
    Review
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Natalie E RiddellDivision of Infection and Immunity, University College London, London, UK. Electronic address: n.riddell@ucl.ac.uk.
Victoria E BurnsSchool of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, UK.
Graham R WallaceSchool of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, UK.
Kate M EdwardsFaculty of Health Sciences, The University of Sydney, Australia.
Mark DraysonSchool of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, UK.
Laura S RedwineDepartment of Psychiatry, University of California San Diego, USA.
Suzi HongDepartment of Psychiatry, University of California San Diego, USA.
Jack C BuiDepartment of Psychiatry, University of California San Diego, USA.
Johannes C FischerInstitute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University Dusseldorf, Germany.
Paul J MillsDepartment of Psychiatry, University of California San Diego, USA.
Jos A BoschDepartment of Clinical Psychology, University of Amsterdam, Amsterdam, The Netherlands. Electronic address: j.a.bosch@bham.ac.uk.

Funding

BNP and Neuroimmune Characteristics of CHF &DepressionR01HL073355 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILLS, PAUL J · 2005 to 2014
$5.6M
NHLBI NIH HHS HL-073355NHLBI NIH HHS R01 HL073355Wellcome Trust
6 · The paper itself

Abstract

objectivesStimuli that activate the sympathetic nervous system, such as acute psychological stress, rapidly invoke a robust mobilization of lymphocytes into the circulation. Experimental animal studies suggest that bone marrow-derived progenitor cells (PCs) also mobilize in response to sympathetic stimulation. Here we tested the effects of acute psychological stress and brief pharmacological β-adrenergic (βAR) stimulation on peripheral PC numbers in humans.

methodsIn two studies, we investigated PC mobilization in response to an acute speech task (n=26) and βAR-agonist (isoproterenol) infusion (n=20). A subset of 8 participants also underwent the infusion protocol with concomitant administration of the βAR-antagonist propranolol. Flow cytometry was used to enumerate lymphocyte subsets, total progenitor cells, total haematopoietic stem cells (HSC), early HSC (multi-lineage potential), late HSC (lineage committed), and endothelial PCs (EPCs).

resultsBoth psychological stress and βAR-agonist infusion caused the expected mobilization of total monocytes and lymphocytes and CD8(+) T lymphocytes. Psychological stress also induced a modest, but significant, increase in total PCs, HSCs, and EPC numbers in peripheral blood. However, infusion of a βAR-agonist did not result in a significant change in circulating PCs.

conclusionPCs are rapidly mobilized by psychological stress via mechanisms independent of βAR-stimulation, although the findings do not exclude βAR-stimulation as a possible cofactor. Considering the clinical and physiological relevance, further research into the mechanisms involved in stress-induced PC mobilization seems warranted.

Indexed as

Adrenergic beta-AgonistsAdrenergic beta-AntagonistsAdultAnxietyBlood PressureCD3 ComplexCD8-Positive T-LymphocytesFemaleHeart RateHumansIsoproterenolMaleMesenchymal Stem CellsMonocytesPropranololReceptors, Adrenergic, betaAdrenergic beta-AgonistsAdrenergic beta-AntagonistsCD3 ComplexIsoproterenolPropranololReceptors, Adrenergic, betaAdrenergicMobilizationProgenitor cellsPsychological stressβAR-stimulation

Identifiers

PMID25747743
PMCPMC4561221

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.