Evidence map›Paper›PMID 25747184›Full record

ArticleNeurobiology of disease2015

Recruitment of the prefrontal cortex and cerebellum in Parkinsonian rats following skilled aerobic exercise.

Zhuo Wang, Yumei Guo, Kalisa G Myers, Ryan Heintz, Daniel P Holschneider

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zhuo WangDepartment of Psychiatry and Behavioral Sciences, University of Southern California, Los Angeles, CA, USA.
Yumei GuoDepartment of Psychiatry and Behavioral Sciences, University of Southern California, Los Angeles, CA, USA.
Kalisa G MyersDepartment of Psychiatry and Behavioral Sciences, University of Southern California, Los Angeles, CA, USA.
Ryan HeintzDepartment of Psychiatry and Behavioral Sciences, University of Southern California, Los Angeles, CA, USA.
Daniel P HolschneiderDepartment of Psychiatry and Behavioral Sciences, University of Southern California, Los Angeles, CA, USA; Departments of Biomedical Engineering, Neurology, Cell and Neurobiology, University of Southern California, Los Angeles, CA, USA. Electronic address: holschne@usc.edu.
University of Southern California · US

Funding

Functional Adaptation of Neural Circuits After Exercise and Basal Ganglia InjuryR01HD060630 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HOLSCHNEIDER, DANIEL PHILIPP · 2010 to 2014
$1.6M
NICHD NIH HHS 1R01HD060630NICHD NIH HHS R01 HD060630
6 · The paper itself

Abstract

Exercise modality and complexity play a key role in determining neurorehabilitative outcome in Parkinson's disease (PD). Exercise training (ET) that incorporates both motor skill training and aerobic exercise has been proposed to synergistically improve cognitive and automatic components of motor control in PD patients. Here we introduced such a skilled aerobic ET paradigm in a rat model of dopaminergic deafferentation. Rats with bilateral, intra-striatal 6-hydroxydopamine lesions were exposed to forced ET for 4weeks, either on a simple running wheel (non-skilled aerobic exercise, NSAE) or on a complex wheel with irregularly spaced rungs (skilled aerobic exercise, SAE). Cerebral perfusion was mapped during horizontal treadmill walking or at rest using [(14)C]-iodoantipyrine 1week after the completion of ET. Regional cerebral blood flow (rCBF) was quantified by autoradiography and analyzed in 3-dimensionally reconstructed brains by statistical parametric mapping. SAE compared to NSAE resulted in equal or greater recovery in motor deficits, as well as greater increases in rCBF during walking in the prelimbic area of the prefrontal cortex, broad areas of the somatosensory cortex, and the cerebellum. NSAE compared to SAE animals showed greater activation in the dorsal caudate-putamen and dorsal hippocampus. Seed correlation analysis revealed enhanced functional connectivity in SAE compared to NSAE animals between the prelimbic cortex and motor areas, as well as altered functional connectivity between midline cerebellum and sensorimotor regions. Our study provides the first evidence for functional brain reorganization following skilled aerobic exercise in Parkinsonian rats, and suggests that SAE compared to NSAE results in enhancement of prefrontal cortex- and cerebellum-mediated control of motor function.

Indexed as

Adrenergic AgentsAnalysis of VarianceAnimalsAutoradiographyBrain MappingCerebellumCerebrovascular CirculationDisease Models, AnimalImaging, Three-DimensionalMotor ActivityMotor SkillsNeural PathwaysOxidopamineParkinsonian DisordersPhysical Conditioning, AnimalPrefrontal CortexAdrenergic AgentsOxidopamineTyrosine 3-MonooxygenaseCerebellumExerciseFunctional brain mappingFunctional connectivityMotor adaptationMotor functionMotor skill learningParkinson's diseasePrefrontal cortexRatsRehabilitation

Identifiers

PMID25747184
PMCPMC4402279
OpenAlexW2006596369

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.