ArticleApplied and environmental microbiology2015
Novel blaROB-1-bearing plasmid conferring resistance to β-lactams in Haemophilus parasuis isolates from healthy weaning pigs.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 56 citations in OpenAlex.
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- Intensive antibiotic treatment of sows with parenteral crystalline ceftiofur and tulathromycin alters the composition of the nasal microbiota of their offspring.Veterinary research · 2023Article
- Characterisation and mobilisation of IncA/C plasmid-mediated antibiotic resistance in Edwardsiella ictaluri.Journal of global antimicrobial resistance · 2023Article
- Origins of transfer establish networks of functional dependencies for plasmid transfer by conjugation.Nucleic acids research · 2023Article
- Immunogenicity and protection against Glaesserella parasuis serotype 13 infection after vaccination with recombinant protein LolA in mice.The Journal of veterinary medical science · 2022Article
- Dosing Regimen of Aditoprim and Sulfamethoxazole Combination for thePharmaceutics · 2022Article
- Genetic Diversity ofVeterinary sciences · 2022Article
- Genomic insight into the integrative conjugative elements from ICEFrontiers in veterinary science · 2022Article
- Molecular characterization of Glaesserella parasuis strains isolated from North America, Europe and Asia by serotyping PCR and LS-PCR.Veterinary research · 2021Article
- Evidence for Establishing the Clinical Breakpoint of Cefquinome against Haemophilus Parasuis in China.Pathogens (Basel, Switzerland) · 2021Article
- Mobile Genetic Elements Drive Antimicrobial Resistance Gene Spread inFrontiers in microbiology · 2021Article
- Molecular Characterization of a Novel Integrative Conjugative Element ICEFrontiers in microbiology · 2020Article
- PK/PD modeling of Ceftiofur Sodium against Haemophilus parasuis infection in pigs.BMC veterinary research · 2019Article
- Characterization of a Novel Conjugative Plasmid inFrontiers in cellular and infection microbiology · 2019Article
- Antimicrobial Resistance inMicrobiology spectrum · 2018Review
- Evidence of Illegitimate Recombination Between TwoFrontiers in microbiology · 2018Article
- Comparative genomic and methylome analysis of non-virulent D74 and virulent Nagasaki Haemophilus parasuis isolates.PloS one · 2018Article
- Epidemiology ofPeerJ · 2018Article
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Haemophilus parasuis, the causative agent of Glässer's disease, is one of the early colonizers of the nasal mucosa of piglets. It is prevalent in swine herds, and lesions associated with disease are fibrinous polyserositis and bronchopneumonia. Antibiotics are commonly used in disease control, and resistance to several antibiotics has been described in H. parasuis. Prediction of H. parasuis virulence is currently limited by our scarce understanding of its pathogenicity. Some genes have been associated with H. parasuis virulence, such as lsgB and group 1 vtaA, while biofilm growth has been associated with nonvirulent strains. In this study, 86 H. parasuis nasal isolates from farms that had not had a case of disease for more than 10 years were obtained by sampling piglets at weaning. Isolates were studied by enterobacterial repetitive intergenic consensus PCR and determination of the presence of lsgB and group 1 vtaA, biofilm formation, inflammatory cell response, and resistance to antibiotics. As part of the diversity encountered, a novel 2,661-bp plasmid, named pJMA-1, bearing the blaROB-1 β-lactamase was detected in eight colonizing strains. pJMA-1 was shown to share a backbone with other small plasmids described in the Pasteurellaceae, to be 100% stable, and to have a lower biological cost than the previously described plasmid pB1000. pJMA-1 was also found in nine H. parasuis nasal strains from a separate collection, but it was not detected in isolates from the lesions of animals with Glässer's disease or in nontypeable Haemophilus influenzae isolates. Altogether, we show that commensal H. parasuis isolates represent a reservoir of β-lactam resistance genes which can be transferred to pathogens or other bacteria.
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