ArticleApplied and environmental microbiology2015
Zoonotic and Potentially Host-Adapted Enterocytozoon bieneusi Genotypes in Sheep and Cattle in Northeast China and an Increasing Concern about the Zoonotic Importance of Previously Considered Ruminant-Adapted Genotypes.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 87 citations in OpenAlex.
- First joint report on the prevalence and genotyping of Cryptosporidium spp., Giardia duodenalis, and Enterocytozoon bieneusi among hospitalized children in Inner Mongolia, China.BMC infectious diseases · 2026Article
- Molecular Prevalence and Genotyping of Enterocytozoon bieneusi in Cattle from Central Algeria.Acta parasitologica · 2026Article
- Molecular Detection ofVeterinary sciences · 2025Article
- Investigation of Infection ofVeterinary sciences · 2025Article
- Molecular prevalence and genetic characterization of Enterocytozoon bieneusi in cattle in a dairy farm in Türkiye.BMC veterinary research · 2025Article
- Investigation of Cryptosporidium spp. and Enterocytozoon bieneusi in free-ranged livestock on the southeastern Qinghai-Xizang Plateau, China.BMC infectious diseases · 2025Article
- Prevalence and genotyping of Enterocytozoon bieneusi in cattle from Shanxi and Inner Mongolia, China.Scientific reports · 2025Article
- Prevalence and zoonotic potential ofFrontiers in veterinary science · 2025Article
- Retrospective Cohort Study of Early versus Delayed Ballon Kyphoplasty Intervention for Osteoporotic Vertebral Fracture Treatment.Medicina (Kaunas, Lithuania) · 2024Article
- Molecular prevalence and genotype identification ofFrontiers in veterinary science · 2024Article
- High genotype diversity and zoonotic potential of Enterocytozoon bieneusi in yaks (Bos grunniens) from Ganzi Tibetan Autonomous Prefecture, Sichuan Province.Parasite (Paris, France) · 2023Article
- Enterocytozoon bieneusi in fecal samples from calves and cows in Austria.Parasitology research · 2023Article
- Seasonal distribution of Cryptosporidium spp., Giardia duodenalis and Enterocytozoon bieneusi in Tibetan sheep in Qinghai, China.Parasites & vectors · 2022Article
- Molecular Identification and Genotyping ofAnimals : an open access journal from MDPI · 2022Article
- Prevalence and Novel Genotypes Identification ofAnimals : an open access journal from MDPI · 2021Article
- Molecular epidemiology and genotype/subtype distribution of Blastocystis sp., Enterocytozoon bieneusi, and Encephalitozoon spp. in livestock: concern for emerging zoonotic infections.Scientific reports · 2021Article
- The global molecular epidemiology of microsporidia infection in sheep and goats with focus on Enterocytozoon bieneusi: a systematic review and meta-analysis.Tropical medicine and health · 2021Review
- Ecological and public health significance ofOne health (Amsterdam, Netherlands) · 2021Review
- Characterization and comparison of the bacterial community between complete intensive and extensive feeding patterns in pigs.AMB Express · 2021Article
- Population genetic analysis suggests genetic recombination is responsible for increased zoonotic potential ofOne health (Amsterdam, Netherlands) · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated fecal specimens from 489 sheep and 537 cattle in multiple cities in northeast China for the prevalence and genetic characteristics of Enterocytozoon bieneusi by PCR and sequencing of the ribosomal internal transcribed spacer. Sixty-eight sheep specimens (13.9%) and 32 cattle specimens (6.0%) were positive for E. bieneusi. Sequence polymorphisms enabled the identification of 9 known genotypes (BEB4, BEB6, CM7, CS-4, EbpC, G, I, J, and OEB1) and 11 new genotypes (NESH1 to NESH6 and NECA1 to NECA5). The genotypes formed two genetic clusters in a phylogenetic analysis, with CS-4, EbpC, G, NESH1 to NESH3, and NECA1 to NECA5 distributed in zoonotic group 1 and BEB4, BEB6, CM7, EbpI, J, OEB1, and NESH4 to NESH6 distributed in potentially host-adapted group 2. Nearly 70% of cases of E. bieneusi infections in sheep were contributed by human-pathogenic genotypes BEB6, CS-4, and EbpC, and over 80% of those in cattle were by genotypes BEB4, CS-4, EbpC, I, and J. The cooccurrence of genotypes BEB4, CS-4, EbpC, I, and J in domestic ruminants and children in northeast China and the identification of BEB6 and EbpC in humans and water in central China imply the possibility of zoonotic transmission. This study also summarizes E. bieneusi genotypes obtained from ruminants worldwide and displays their host ranges, geographical distributions, and phylogenetic relationships. The data suggest a host range expansion in some group 2 genotypes (notably BEB4, BEB6, I, and J) that were previously considered to be adapted to ruminants. We should be concerned about the increasing zoonotic importance of group 2 genotypes with low host specificity.
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