ArticleApplied and environmental microbiology2015
Lactococcal 949 group phages recognize a carbohydrate receptor on the host cell surface.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Members of theMicrobial genomics · 2026Article
- Resistance to the Bacteriocin Lcn972 Deciphered by Genome Sequencing.Microorganisms · 2023Article
- Phage Adsorption to Gram-Positive Bacteria.Viruses · 2023Review
- Host genetic requirements for DNA release of lactococcal phage TP901-1.Microbial biotechnology · 2022Article
- Article
- Bacteriophage-host interactions as a platform to establish the role of phages in modulating the microbial composition of fermented foods.Microbiome research reports · 2022Review
- Host-encoded, cell surface-associated exopolysaccharide required for adsorption and infection by lactococcal P335 phage subtypes.Frontiers in microbiology · 2022Article
- Article
- Cell wall polysaccharides of Gram positive ovococcoid bacteria and their role as bacteriophage receptors.Computational and structural biotechnology journal · 2021Review
- Lysogenization of a Lactococcal Host with Three Distinct Temperate Phages Provides Homologous and Heterologous Phage Resistance.Microorganisms · 2020Article
- Fitness Trade-Offs Resulting from Bacteriophage Resistance Potentiate Synergistic Antibacterial Strategies.Infection and immunity · 2020Review
- A Specific Sugar Moiety in the Lactococcus lactis Cell Wall Pellicle Is Required for Infection by CHPC971, a Member of the Rare 1706 Phage Species.Applied and environmental microbiology · 2019Article
- Vgas: A Viral Genome Annotation System.Frontiers in microbiology · 2019Article
- TheFrontiers in microbiology · 2019Article
- Targeting mechanisms of tailed bacteriophages.Nature reviews. Microbiology · 2018Review
- A Decade of Streptococcus thermophilus Phage Evolution in an Irish Dairy Plant.Applied and environmental microbiology · 2018Article
- Phage Biodiversity in Artisanal Cheese Wheys Reflects the Complexity of the Fermentation Process.Viruses · 2017Article
- Genetic and functional characterisation of the lactococcal P335 phage-host interactions.BMC genomics · 2017Article
- Global Survey and Genome Exploration of Bacteriophages Infecting the Lactic Acid BacteriumFrontiers in microbiology · 2017Article
- Identification and Analysis of a Novel Group of Bacteriophages Infecting the Lactic Acid Bacterium Streptococcus thermophilus.Applied and environmental microbiology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lactococcal bacteriophages represent one of the leading causes of dairy fermentation failure and product inconsistencies. A new member of the lactococcal 949 phage group, named WRP3, was isolated from cheese whey from a Sicilian factory in 2011. The genome sequence of this phage was determined, and it constitutes the largest lactococcal phage genome currently known, at 130,008 bp. Detailed bioinformatic analysis of the genomic region encoding the presumed initiator complex and baseplate of WRP3 has aided in the functional assignment of several open reading frames (ORFs), particularly that for the receptor binding protein required for host recognition. Furthermore, we demonstrate that the 949 phages target cell wall phospho-polysaccharides as their receptors, accounting for the specificity of the interactions of these phages with their lactococcal hosts. Such information may ultimately aid in the identification of strains/strain blends that do not present the necessary saccharidic target for infection by these problematic phages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.