ArticleCritical care medicine2015
Association of cumulative dose of haloperidol with next-day delirium in older medical ICU patients.
Article in Critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Non-pharmacological interventions for delirium in the pediatric population: a systematic review with narrative synthesis.BMC pediatrics · 2024Pooled it
- Predisposing and Precipitating Factors Associated With Delirium: A Systematic Review.JAMA network open · 2023Pooled it
- Efficacy of haloperidol to decrease the burden of delirium in adult critically ill patients: the EuRIDICE randomized clinical trial.Critical care (London, England) · 2023Trial
- A Comparative Analysis of the Effects of Haloperidol and Dexmedetomidine on QTc Interval Prolongation during Delirium Treatment in Intensive Care Units.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2024Article
- Article
- Sepsis-Associated Delirium: A Narrative Review.Journal of clinical medicine · 2023Review
- Haloperidol, clonidine and resolution of delirium in critically ill patients: a prospective cohort study.Intensive care medicine · 2021Article
- Benzodiazepines and Development of Delirium in Critically Ill Children: Estimating the Causal Effect.Critical care medicine · 2018Observational
- Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study.Intensive care medicine · 2018Article
- Delirium and Mortality in Critically Ill Children: Epidemiology and Outcomes of Pediatric Delirium.Critical care medicine · 2017Article
- Dexmedetomidine for hyperactive delirium: worth further study.Journal of thoracic disease · 2016Article
- The authors reply.Critical care medicine · 2015Article
- Use of Self-Matching to Control for Stable Patient Characteristics While Addressing Time-Varying Confounding on Treatment Effect: A Case Study of Older Intensive Care Patients.International journal of statistics in medical researchArticle
- An Empirical Method of Detecting Time-Dependent Confounding: An Observational Study of Next Day Delirium in a Medical ICU.International journal of statistics in medical researchArticle
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3 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo evaluate the association between cumulative dose of haloperidol and next-day diagnosis of delirium in a cohort of older medical ICU patients, with adjustment for its time-dependent confounding with fentanyl and intubation.
designProspective, observational study.
settingMedical ICU at an urban, academic medical center. PATIENTS: Age 60 years and older admitted to the medical ICU who received at least one dose of haloperidol (n = 93). Of these, 72 patients were intubated at some point in their medical ICU stay, whereas 21 were never intubated.
interventionsNone. MEASUREMENTS AND MAIN
resultsDetailed data were collected concerning time, dosage, route of administration of all medications, as well as for important clinical covariates, and daily status of intubation and delirium using the confusion assessment method for the ICU and a chart-based algorithm. Among nonintubated patients, and after adjustment for time-dependent confounding and important covariates, each additional cumulative milligram of haloperidol was associated with 5% higher odds of next-day delirium with odds ratio of 1.05 (credible interval [CI], 1.02-1.09). After adjustment for time-dependent confounding and covariates, intubation was associated with a five-fold increase in odds of next-day delirium with odds ratio of 5.66 (CI, 2.70-12.02). Cumulative dose of haloperidol among intubated patients did not change their already high likelihood of next-day delirium. After adjustment for time-dependent confounding, the positive associations between indicators of intubation and of cognitive impairment and next-day delirium became stronger.
conclusionsThese results emphasize the need for more studies regarding the efficacy of haloperidol for treatment of delirium among older medical ICU patients and demonstrate the value of assessing nonintubated patients.
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