ArticleBehavioural brain research2015
The impact of social stress during adolescence or adulthood and coping strategy on cognitive function of female rats.
Article in Behavioural brain research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Sleep patterns predicting stress resilience are dependent on sex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Gains and Losses: Resilience to Social Defeat Stress in Adolescent Female Mice.Biological psychiatry · 2024Article
- Coping in Mid- to Late Life and Risk of Mild Cognitive Impairment Subtypes and Dementia: A JPHC Saku Mental Health Study.Journal of Alzheimer's disease : JAD · 2022Article
- Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibility in male, but not female, mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Sex-dependent long-term effects of prepubescent stress on the posterior parietal cortex.Neurobiology of stress · 2021Article
- Chronic adolescent stress causes sustained impairment of cognitive flexibility and hippocampal synaptic strength in female rats.Neurobiology of stress · 2021Article
- The Role of PDE11A4 in Social Isolation-Induced Changes in Intracellular Signaling and Neuroinflammation.Frontiers in pharmacology · 2021Article
- Prior stress followed by a novel stress challenge results in sex-specific deficits in behavioral flexibility and changes in gene expression in rat medial prefrontal cortex.Hormones and behavior · 2020Article
- Social instability in adolescence differentially alters dendritic morphology in the medial prefrontal cortex and its response to stress in adult male and female rats.Developmental neurobiology · 2019Article
- Corticotropin-Releasing Factor (CRF) circuit modulation of cognition and motivation.Neuroscience and biobehavioral reviews · 2019Review
- Chronic stress produces enduring sex- and region-specific alterations in novel stress-induced c-Fos expression.Neurobiology of stress · 2019Article
- Age- and sex-dependent impact of repeated social stress on morphology of rat prefrontal cortex pyramidal neurons.Neurobiology of stress · 2019Article
- Sex Differences in Risk and Resilience: Stress Effects on the Neural Substrates of Emotion and Motivation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Review
- Translational relevance of rodent models of hypothalamic-pituitary-adrenal function and stressors in adolescence.Neurobiology of stress · 2017Review
- Age- and Sex-Dependent Impact of Repeated Social Stress on Intrinsic and Synaptic Excitability of the Rat Prefrontal Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Ranking Cognitive Flexibility in a Group Setting of Rhesus Monkeys with a Set-Shifting Procedure.Frontiers in behavioral neuroscience · 2017Article
- Synaptic Plasticity, Metaplasticity and Depression.Current neuropharmacology · 2017Review
- Adolescent Social Stress Produces an Enduring Activation of the Rat Locus Coeruleus and Alters its Coherence with the Prefrontal Cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Social Support Modulates Stress-Related Gene Expression in Various Brain Regions of Piglets.Frontiers in behavioral neuroscience · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The age of stressor exposure can determine its neurobehavioral impact. For example, exposure of adolescent male rats to resident-intruder stress impairs cognitive flexibility in adulthood. The current study examined the impact of this stressor in female rats. Rats were exposed to resident-intruder stress during early adolescence (EA), mid-adolescence (MA) or adulthood (Adult). They were tested in an operant strategy-shifting task for side discrimination (SD), reversal learning (REV) and strategy set-shifting (SHIFT) the following week. Performance varied with age, stress and coping style. MA and EA rats performed SD and SHIFT better than other ages, respectively. Social stress impaired performance in rats depending on their coping strategy as determined by a short (SL) or long (LL) latency to become subordinate. SL rats were impaired in SD and REV, whereas EA-LL rats were impaired in SHIFT. These impairing effects of female adolescent stress did not endure into adulthood. Strategy set-shifting performance for female adolescents was positively correlated with medial prefrontal cortex (mPFC) activation as indicated by c-fos expression suggesting that this region is engaged during task performance. This contrasts with the inverse relationship between these indices reported for male adolescent rats. Together, the results demonstrate that social stress produces cognitive impairments for female rats that depend on age and coping style but unlike males, the impairing effects of female adolescent social stress are immediate and do not endure into adulthood. Sex differences in the impact of adolescent social stress on cognition may reflect differences in mPFC engagement during the task.
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