Observational studyThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2015
Subjective Cognitive Complaints, Personality and Brain Amyloid-beta in Cognitively Normal Older Adults.
Observational study in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
79 citing papers in PubMed, 3 syntheses or guidelines pooled it, 139 citations in OpenAlex.
- SCD-plus features and AD biomarkers in cognitively unimpaired samples: A meta-analytic approach for nine cohort studies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Personality Associations With Amyloid and Tau: Results From the Baltimore Longitudinal Study of Aging and Meta-analysis.Biological psychiatry · 2022Pooled it
- Subjective Cognitive Impairment and Affective Symptoms: A Systematic Review.The Gerontologist · 2016Pooled it
- Neurobiological markers across joint profiles of subjective cognitive decline and objective cognitive function in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Trial
- Effects of multisession frontoparietal network anodal tDCS and cognitive rehabilitation on subjective cognitive impairment: a double-blind RCT.BMC neurology · 2026Trial
- Effects of Meditation and Music-Listening on Blood Biomarkers of Cellular Aging and Alzheimer's Disease in Adults with Subjective Cognitive Decline: An Exploratory Randomized Clinical Trial.Journal of Alzheimer's disease : JAD · 2018Trial
- Meditation and Music Improve Memory and Cognitive Function in Adults with Subjective Cognitive Decline: A Pilot Randomized Controlled Trial.Journal of Alzheimer's disease : JAD · 2017Trial
- Effects of Meditation versus Music Listening on Perceived Stress, Mood, Sleep, and Quality of Life in Adults with Early Memory Loss: A Pilot Randomized Controlled Trial.Journal of Alzheimer's disease : JAD · 2016Trial
- Depression and anxiety modify cognitive concerns associated with amyloid and early clinical impairment.Neuropsychology · 2026Article
- Motor speech markers of Alzheimer's risk.GeroScience · 2026Article
- Clinical definition, biological characterization, and detection guidelines of subjective cognitive decline due to Alzheimer's disease and related dementia: A position paper from ISTAART SCD PIA.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The Relationship Between Subjective Cognitive Decline and Objective Cognitive Performance in Older Adults With Treatment-Resistant Late-Life Depression: The Role of Depression Severity.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025Article
- Objective Assessment of Cognition for Detecting Subjective Cognitive Decline Is More Accurate than Subjective Estimations: The Role of Trait Affect.Journal of Intelligence · 2025Article
- Subjective cognitive decline among diverse older adults: Prevalence and associations with objective cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Body mass index changes and trajectories from midlife to late-life: association with subjective cognitive complaints in a 30-year Women's cohort study.Age and ageing · 2025Article
- Voxel-wise hemispheric Amyloid Asymmetry and its association with cerebral metabolism and grey matter density in cognitively normal older adults.medRxiv : the preprint server for health sciences · 2024Article
- Mid-life adherence to the Dietary Approaches to Stop Hypertension (DASH) diet and late-life subjective cognitive complaints in women.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Dorsal and ventral fronto-amygdala networks underlie risky decision-making in age-related cognitive decline.GeroScience · 2024Article
- The Taxonomy of Subjective Cognitive Decline: Proposal and First Clinical Evidence from the Geneva Memory Clinic Cohort.Neuro-degenerative diseases · 2024Article
- Understanding factors associated with the trajectory of subjective cognitive complaints in groups with similar objective cognitive trajectories.Alzheimer's research & therapy · 2023Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveSubjective cognitive complaints in otherwise normal aging are common but may be associated with preclinical Alzheimer disease in some individuals. Little is known about who is mostly likely to show associations between cognitive complaints and preclinical Alzheimer pathology. We sought to demonstrate associations between subjective complaints and brain amyloid-β in cognitively normal older adults; and to explore personality factors as potential moderators of this association.
designCross-sectional observational study.
settingClinical neuroimaging research center.
participantsCommunity volunteer sample of 92 healthy older adults, screened for normal cognition with comprehensive neuropsychological evaluation. MEASUREMENTS: Subjective cognitive self-report measures included the Memory Functioning Questionnaire (MFQ), Cognitive Failures Questionnaire, and the Subjective Cognitive Complaint Scale. Personality was measured with the NEO Five Factor Inventory. Brain amyloid-β deposition was assessed with Pittsburgh compound B (PiB)-PET imaging.
resultsOne of three cognitive complaint measures, the MFQ, was associated with global PiB retention (standardized beta = -0.230, p = 0.046, adjusting for age, sex and depressive symptoms). Neuroticism moderated this association such that only high neuroticism individuals showed the predicted pattern of high complaint-high amyloid-β association.
conclusionEvidence for association between subjective cognition and brain amyloid-β deposition in healthy older adults is demonstrable but measure-specific. Neuroticism may moderate the MFQ-amyloid-β association such that it is observed in the context of higher trait neuroticism. Subjective cognitive complaints and neuroticism may reflect a common susceptibility toward psychological distress and negative affect, which are in turn risk factors for cognitive decline in aging and incident Alzheimer disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.