Evidence map›Paper›PMID 25746444›Full record

ArticleLangmuir : the ACS journal of surfaces and colloids2015

New poly(amino acid methacrylate) brush supports the formation of well-defined lipid membranes.

Anita C Blakeston, Abdullah M Alswieleh, George R Heath, Johannes S Roth, Peng Bao, Nan Cheng, Steven P Armes, Graham J Leggett, Richard J Bushby, Stephen D Evans

Abstract read
In one paragraph

Article in Langmuir : the ACS journal of surfaces and colloids, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Topography design in model membranes: Where biology meets physics.Experimental biology and medicine (Maywood, N.J.) · 2019
    Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anita C Blakeston†Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, United Kingdom.
Abdullah M Alswieleh‡Department of Chemistry, University of Sheffield, Sheffield S3 7HF, United Kingdom.
George R Heath†Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, United Kingdom.
Johannes S Roth†Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, United Kingdom.
Peng Bao†Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, United Kingdom.
Nan Cheng‡Department of Chemistry, University of Sheffield, Sheffield S3 7HF, United Kingdom.
Steven P Armes‡Department of Chemistry, University of Sheffield, Sheffield S3 7HF, United Kingdom.
Graham J Leggett‡Department of Chemistry, University of Sheffield, Sheffield S3 7HF, United Kingdom.
Richard J Bushby†Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, United Kingdom.
Stephen D Evans†Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, United Kingdom.

Funding

European Research Council 320372
6 · The paper itself

Abstract

A novel poly(amino acid methacrylate) brush comprising zwitterionic cysteine groups (PCysMA) was utilized as a support for lipid bilayers. The polymer brush provides a 12-nm-thick cushion between the underlying hard support and the aqueous phase. At neutral pH, the zeta potential of the PCysMA brush was ∼-10 mV. Cationic vesicles containing >25% DOTAP were found to form a homogeneous lipid bilayer, as determined by a combination of surface analytical techniques. The lipid mobility as measured by FRAP (fluorescence recovery after photobleaching) gave diffusion coefficients of ∼1.5 μm(2) s(-1), which are comparable to those observed for lipid bilayers on glass substrates.

Indexed as

Cell MembraneCysteineLipid BilayersModels, MolecularMolecular ConformationPhosphorylcholinePolymerizationPolymersPolymethacrylic AcidsSurface PropertiesCysteineLipid BilayersPhosphorylcholinepoly(2-methacryloyloxyethyl-phosphorylcholine)PolymersPolymethacrylic Acids

Identifiers

PMID25746444
PMCPMC4444997

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.