ArticleNucleus (Austin, Tex.)2015
Nuclear envelope regulates the circadian clock.
Article in Nucleus (Austin, Tex.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Circadian system and aging: where both times interact.Frontiers in aging · 2025Review
- Mistimed food intake and sleep alters 24-hour time-of-day patterns of the human plasma proteome.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Daily rhythms of behavior and physiology arise from endogenous circadian clocks. At the molecular level, the circadian clock consists of intricate transcriptional and post-transcriptional feedback loops that drive 24h rhythms in a vast repertoire of basic cellular processes. The nuclear envelope, as a fundamental component of the cell, has been shown to function as a global transcriptional regulatory machinery. Recently we found that nuclear envelope proteins regulate the circadian clock both in the mammalian system and in fruit flies. One of these proteins, MAN1, impinges on the clock by binding to the promoter region of the core clock gene BMAL1 and enhances its transcription. Here we discuss about other potential mechanisms employed by nuclear envelope proteins to regulate the circadian clock and possible biological relevance of these modulations.
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