Evidence map›Paper›PMID 25746204›Full record

ReviewCritical reviews in therapeutic drug carrier systems2015

Nanostructured platforms for the sustained and local delivery of antibiotics in the treatment of osteomyelitis.

Vuk Uskokovic

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Critical reviews in therapeutic drug carrier systems, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 94 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Coaxial electrospun fibers for control release of vancomycin and diclofenac in osteomyelitis management.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Bisphosphonates for delivering drugs to bone.British journal of pharmacology · 2021
    Review
  17. Review
  18. Review
  19. Article
  20. Waiting for Aπαταω: 250 Years Later.Foundations of science · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Vuk UskokovicAdvanced Materials and Nanobiotechnology Laboratory, Richard and Loan Hill Department of Bioengineering, College of Medicine, University of Illinois at Chicago, 851 South Morgan St, #205 Chicago, Illinois, 60607-7052.
University of Illinois Chicago · US

Funding

Osteogenic Calcium Phosphate Nanoparticles with Designable Drug Release KineticsR00DE021416 · NIDCR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI USKOKOVIC, VUK · 2014 to 2016
$727k
NIDCR NIH HHS R00 DE021416
6 · The paper itself

Abstract

This article provides a critical view of the current state of the development of nanoparticulate and other solid-state carriers for the local delivery of antibiotics in the treatment of osteomyelitis. Mentioned are the downsides of traditional means for treating bone infection, which involve systemic administration of antibiotics and surgical debridement, along with the rather imperfect local delivery options currently available in the clinic. Envisaged are more sophisticated carriers for the local and sustained delivery of antimicrobials, including bioresorbable polymeric, collagenous, liquid crystalline, and bioglass- and nanotube-based carriers, as well as those composed of calcium phosphate, the mineral component of bone and teeth. A special emphasis is placed on composite multifunctional antibiotic carriers of a nanoparticulate nature and on their ability to induce osteogenesis of hard tissues demineralized due to disease. An ideal carrier of this type would prevent the long-term, repetitive, and systemic administration of antibiotics and either minimize or completely eliminate the need for surgical debridement of necrotic tissue. Potential problems faced by even hypothetically "perfect" antibiotic delivery vehicles are mentioned too, including (i) intracellular bacterial colonies involved in recurrent, chronic osteomyelitis; (ii) the need for mechanical and release properties to be adjusted to the area of surgical placement; (iii) different environments in which in vitro and in vivo testings are carried out; (iv) unpredictable synergies between drug delivery system components; and (v) experimental sensitivity issues entailing the increasing subtlety of the design of nanoplatforms for the controlled delivery of therapeutics.

Indexed as

Drug Delivery SystemsAnimalsAnti-Bacterial AgentsDebridementDelayed-Action PreparationsDrug CarriersDrug DesignHumansNanoparticlesNanostructuresOsteomyelitisAnti-Bacterial AgentsDelayed-Action PreparationsDrug Carriers

Identifiers

PMID25746204
PMCPMC4406243
OpenAlexW2033538079

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.