Evidence map›Paper›PMID 25745847›Full record

ArticleStem cells and development2015

Mesenchymal Stem Cell Therapy Alleviates Interstitial Cystitis by Activating Wnt Signaling Pathway.

Miho Song, Jisun Lim, Hwan Yeul Yu, Junsoo Park, Ji-Youn Chun, Jaeho Jeong, Jinbeom Heo, Hyunsook Kang, YongHwan Kim, Yong Mee Cho and 7 more

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Article in Stem cells and development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
9.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 71 citations in OpenAlex.

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  19. Human Umbilical Cord Mesenchymal Stem Cell Therapy Mitigates Interstitial Cystitis by Inhibiting Mast Cells.Medical science monitor : international medical journal of experimental and clinical research · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 2 countries.

Miho Song1 Department of Urology, Asan Medical Center, University of Ulsan College of Medicine , Seoul, Korea.
Jisun Lim2 Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine , Seoul, Korea.
Hwan Yeul Yu1 Department of Urology, Asan Medical Center, University of Ulsan College of Medicine , Seoul, Korea.
Junsoo Park1 Department of Urology, Asan Medical Center, University of Ulsan College of Medicine , Seoul, Korea.
Ji-Youn Chun1 Department of Urology, Asan Medical Center, University of Ulsan College of Medicine , Seoul, Korea.
Jaeho Jeong2 Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine , Seoul, Korea.
Jinbeom Heo2 Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine , Seoul, Korea.
Hyunsook Kang2 Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine , Seoul, Korea.
YongHwan Kim2 Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine , Seoul, Korea.
Yong Mee Cho5 Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine , Seoul, Korea.
Seong Who Kim6 Department of Biochemistry and Molecular Biology, Asan Medical Center, University of Ulsan College of Medicine , Seoul, Korea.
Wonil Oh7 Biomedical Research Institute, MEDIPOST Co., Ltd. , Seoul, Korea.
Soo Jin Choi7 Biomedical Research Institute, MEDIPOST Co., Ltd. , Seoul, Korea.
Sung-Wuk Jang2 Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine , Seoul, Korea.
Sanghyeok Park2 Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine , Seoul, Korea.
Dong-Myung Shin2 Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine , Seoul, Korea.
Myung-Soo Choo1 Department of Urology, Asan Medical Center, University of Ulsan College of Medicine , Seoul, Korea.
Ulsan College · KRMedipost (South Korea) · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interstitial cystitis (IC) is a syndrome characterized by urinary urgency, frequency, pelvic pain, and nocturia in the absence of bacterial infection or identifiable pathology. IC is a devastating disease that certainly decreases quality of life. However, the causes of IC remain unknown and no effective treatments or cures have been developed. This study evaluated the therapeutic potency of using human umbilical cord-blood-derived mesenchymal stem cells (UCB-MSCs) to treat IC in a rat model and to investigate its responsible molecular mechanism. IC was induced in 10-week-old female Sprague-Dawley rats via the instillation of 0.1 M HCl or phosphate-buffered saline (PBS; sham). After 1 week, human UCB-MSC (IC+MSC) or PBS (IC) was directly injected into the submucosal layer of the bladder. A single injection of human UCB-MSCs significantly attenuated the irregular and decreased voiding interval in the IC group. Accordingly, denudation of the epithelium and increased inflammatory responses, mast cell infiltration, neurofilament production, and angiogenesis observed in the IC bladders were prevented in the IC+MSC group. The injected UCB-MSCs successfully engrafted to the stromal and epithelial tissues and activated Wnt signaling cascade. Interference with Wnt and epidermal growth factor receptor activity by small molecules abrogated the benefits of MSC therapy. This is the first report that provides an experimental evidence of the therapeutic effects and molecular mechanisms of MSC therapy to IC using an orthodox rat animal model. Our findings not only provide the basis for clinical trials of MSC therapy to IC but also advance our understanding of IC pathophysiology.

Indexed as

Mesenchymal Stem Cell TransplantationAnimalsCell- and Tissue-Based TherapyCell ProliferationCells, CulturedCystitis, InterstitialEpidermal Growth FactorFemaleFetal BloodHumansMesenchymal Stem CellsRatsRats, Sprague-DawleyUrinary BladderUrinationUrination DisordersEpidermal Growth FactorWnt Proteins

Identifiers

PMID25745847
PMCPMC4499842
OpenAlexW1579133082

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.