Evidence map›Paper›PMID 25745640›Full record

ArticleJournal of Parkinson's disease and Alzheimer's disease2014

The Broad Impact of TOM40 on Neurodegenerative Diseases in Aging.

William K Gottschalk, Michael W Lutz, Yu Ting He, Ann M Saunders, Daniel K Burns, Allen D Roses, Ornit Chiba-Falek

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Parkinson's disease and Alzheimer's disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. bioRxiv : the preprint server for biology · 2026
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  20. Geriatrics (Basel, Switzerland) · 2022
    Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

William K GottschalkDepartment of Neurology, Duke University Medical Center, Durham, NC 27710, USA ; Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Department of Neurology, Duke University Medical Center, Durham, NC 27710, USA.
Michael W LutzDepartment of Neurology, Duke University Medical Center, Durham, NC 27710, USA ; Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Department of Neurology, Duke University Medical Center, Durham, NC 27710, USA.
Yu Ting HeDepartment of Neurology, Duke University Medical Center, Durham, NC 27710, USA.
Ann M SaundersDepartment of Neurology, Duke University Medical Center, Durham, NC 27710, USA ; Zinfandel Pharmaceuticals, Chapel Hill, NC, USA.
Daniel K BurnsZinfandel Pharmaceuticals, Chapel Hill, NC, USA.
Allen D RosesDepartment of Neurology, Duke University Medical Center, Durham, NC 27710, USA ; Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Department of Neurology, Duke University Medical Center, Durham, NC 27710, USA ; Zinfandel Pharmaceuticals, Chapel Hill, NC, USA.
Ornit Chiba-FalekDepartment of Neurology, Duke University Medical Center, Durham, NC 27710, USA ; Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Department of Neurology, Duke University Medical Center, Durham, NC 27710, USA.
Duke Medical Center · US

Funding

Role of the TOMM40 poly-T variant in the pathogenesis of Alzheimer's diseaseR01AG040370 · NIA · DUKE UNIVERSITY · PI CHIBA-FALEK, ORNIT · 2013 to 2017
$2.2M
Lewy body neuropathologies and SNCA gene: variants expression and splicingR01NS085011 · NINDS · DUKE UNIVERSITY · PI CHIBA-FALEK, ORNIT · 2013 to 2017
$1.8M
NIA NIH HHS R01 AG040370NINDS NIH HHS R01 NS085011
6 · The paper itself

Abstract

Mitochondrial dysfunction is an important factor in the pathogenesis of age-related diseases, including neurodegenerative diseases like Alzheimer's and Parkinson's spectrum disorders. A polymorphism in Translocase of the Outer Mitochondrial Membrane - 40 kD (

Indexed as

Alzheimer’s DiseaseAPOEMitochondriaPARK2Parkinson’s DiseasePINK1Regulation Of Gene ExpressionSNCATOM ComplexTOMM40

Identifiers

PMID25745640
PMCPMC4346331
OpenAlexW40515872

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.