Evidence map›Paper›PMID 25745629›Full record

ArticleFrontiers in physics2014

Exercise training reinstates cortico-cortical sensorimotor functional connectivity following striatal lesioning: development and application of a subregional-level analytic toolbox for perfusion autoradiographs of the rat brain.

Yu-Hao Peng, Ryan Heintz, Zhuo Wang, Yumei Guo, Kalisa G Myers, Oscar U Scremin, Jean-Michel I Maarek, Daniel P Holschneider

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yu-Hao PengDepartment of Biomedical Engineering, Viterbi School of Engineering, School of Medicine, University of Southern California, Los Angeles, CA, USA.
Ryan HeintzDepartment of Psychiatry and the Behavioral Sciences, Keck School of Medicine, School of Medicine, University of Southern California, Los Angeles, CA, USA.
Zhuo WangDepartment of Psychiatry and the Behavioral Sciences, Keck School of Medicine, School of Medicine, University of Southern California, Los Angeles, CA, USA.
Yumei GuoDepartment of Psychiatry and the Behavioral Sciences, Keck School of Medicine, School of Medicine, University of Southern California, Los Angeles, CA, USA.
Kalisa G MyersDepartment of Psychiatry and the Behavioral Sciences, Keck School of Medicine, School of Medicine, University of Southern California, Los Angeles, CA, USA.
Oscar U ScreminResearch Service, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA ; Physiology Department, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Jean-Michel I MaarekDepartment of Biomedical Engineering, Viterbi School of Engineering, School of Medicine, University of Southern California, Los Angeles, CA, USA.
Daniel P HolschneiderDepartment of Biomedical Engineering, Viterbi School of Engineering, School of Medicine, University of Southern California, Los Angeles, CA, USA ; Department of Psychiatry and the Behavioral Sciences, Keck School of Medicine, School of Medicine, University of Southern California, Los Angeles, CA, USA.
University of Southern California · USUniversity of California, Los Angeles · US

Funding

Functional Adaptation of Neural Circuits After Exercise and Basal Ganglia InjuryR01HD060630 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HOLSCHNEIDER, DANIEL PHILIPP · 2010 to 2014
$1.6M
NICHD NIH HHS R01 HD060630
6 · The paper itself

Abstract

Current rodent connectome projects are revealing brain structural connectivity with unprecedented resolution and completeness. How subregional structural connectivity relates to subregional functional interactions is an emerging research topic. We describe a method for standardized, mesoscopic-level data sampling from autoradiographic coronal sections of the rat brain, and for correlation-based analysis and intuitive display of cortico-cortical functional connectivity (FC) on a flattened cortical map. A graphic user interface "Cx-2D" allows for the display of significant correlations of individual regions-of-interest, as well as graph theoretical metrics across the cortex. Cx-2D was tested on an autoradiographic data set of cerebral blood flow (CBF) of rats that had undergone bilateral striatal lesions, followed by 4 weeks of aerobic exercise training or no exercise. Effects of lesioning and exercise on cortico-cortical FC were examined during a locomotor challenge in this rat model of Parkinsonism. Subregional FC analysis revealed a rich functional reorganization of the brain in response to lesioning and exercise that was not apparent in a standard analysis focused on CBF of isolated brain regions. Lesioned rats showed diminished degree centrality of lateral primary motor cortex, as well as neighboring somatosensory cortex-changes that were substantially reversed in lesioned rats following exercise training. Seed analysis revealed that exercise increased positive correlations in motor and somatosensory cortex, with little effect in non-sensorimotor regions such as visual, auditory, and piriform cortex. The current analysis revealed that exercise partially reinstated sensorimotor FC lost following dopaminergic deafferentation. Cx-2D allows for standardized data sampling from images of brain slices, as well as analysis and display of cortico-cortical FC in the rat cerebral cortex with potential applications in a variety of autoradiographic and histologic studies.

Indexed as

brain mappingcerebral cortexdopamineexercisefunctional connectivitymotor trainingParkinson’s Diseasesoftware

Identifiers

PMID25745629
PMCPMC4347897
OpenAlexW2067261776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.