Evidence map›Paper›PMID 25745556›Full record

ReviewFluids and barriers of the CNS2015

The quest for a better insight into physiology of fluids and barriers of the brain: the exemplary career of Joseph D. Fenstermacher.

Adam Chodobski, Jean-François Ghersi-Egea, Charles Nicholson, Tavarekere N Nagaraja, Joanna Szmydynger-Chodobska

Abstract readReview
In one paragraph

Review in Fluids and barriers of the CNS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. The Glymphatic Pathway: Waste Removal from the CNS via Cerebrospinal Fluid Transport.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2017
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Adam ChodobskiDepartment of Emergency Medicine, Neurotrauma and Brain Barriers Research Laboratory, The Warren Alpert Medical School of Brown University, Coro Center West, Room 112, 1 Hoppin Street, Providence, RI 02903 USA.
Jean-François Ghersi-EgeaBlood-Brain Interface Group, Oncoflam Team and BIP Platform INSERM U 1028, CNRS UMR5292 Lyon Neuroscience Research Center, Faculté de Médecine RTH Laennec, Rue Guillaume Paradin, Cedex 08, 69372 Lyon, France.
Charles NicholsonDepartment of Neuroscience and Physiology, NYU School of Medicine, MSB 460, 550 First Avenue, New York, NY 10016 USA.
Tavarekere N NagarajaDepartment of Anesthesiology, Henry Ford Hospital, 2799 West Grand Blvd., Detroit, MI 48202-2689 USA.
Joanna Szmydynger-ChodobskaDepartment of Emergency Medicine, Neurotrauma and Brain Barriers Research Laboratory, The Warren Alpert Medical School of Brown University, Coro Center West, Room 112, 1 Hoppin Street, Providence, RI 02903 USA.

Funding

DIFFUSION OF SUBSTANCES THROUGH THE BRAINR01NS028642 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NICHOLSON, CHARLES · 1990 to 2013
$4.4M
NINDS NIH HHS R01 NS028642
6 · The paper itself

Abstract

In June 2014 Dr. Joseph D. Fenstermacher celebrated his 80th birthday, which was honored by the symposium held in New London, NH, USA. This review discusses Fenstermacher's contribution to the field of fluids and barriers of the CNS. Specifically, his fundamental work on diffusion of molecules within the brain extracellular space and the research on properties of the blood-brain barrier in health and disease are described. Fenstermacher's early research on cerebrospinal fluid dynamics and the regulation of cerebral blood flow is also reviewed, followed by the discussion of his more recent work involving the use of magnetic resonance imaging.

Indexed as

Brain extracellular spaceCerebral blood flowCerebrospinal fluidDiffusionMRI contrast agentRadiolabelled tracersTumour therapyVentriculocisternal perfusion

Identifiers

PMID25745556
PMCPMC4350980

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.