ArticleInternational journal of endocrinology and metabolism2015
The effects of vitamin d on insulin release from isolated islets of rats.
Article in International journal of endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Vitamin D Deficiency Is Inversely Associated with Homeostatic Model Assessment of Insulin Resistance.Nutrients · 2021Pooled it
- Pooled it
- Vitamin D deficiency and VDR gene polymorphism FokI (rs2228570) are associated with diabetes mellitus in adults: COVID-inconfidentes study.Diabetology & metabolic syndrome · 2024Article
- Differences of Serum 25- (OH) D3 Level and Adverse Pregnancy Outcomes between Women with Gestational Diabetes and Healthy Pregnant Women.Iranian journal of public health · 2021Article
- Vitamin D Increases Glucose Stimulated Insulin Secretion from Insulin Producing Beta Cells (INS1E).International journal of endocrinology and metabolism · 2019Article
- Calcium and vitamin DEuropean journal of nutrition · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVitamin D (vit D) affects glucose metabolism. Receptors of vitamin D have been identified in β cells and studies show that vitamin D deficiency reduces glucose-stimulated insulin secretion (GSIS).
objectivesThe aim of this study was to examine the effect of vitamin D on insulin release from isolated islets of rats. MATERIALS AND
methodsIslets were isolated from male Wistar rats, weighing 200-250 grams, using the collagenase digestion method. Insulin release was assessed following 24 and 48 hours coincubation of islets with vitamin D (0.1, 1 and 10 nM) and glucose (5.6, 11.1 and 16.7 mM). In addition, islets were preincubated with vitamin D for 24 and 48 hours and GSIS was assessed for one hour in the presence of 5.6 and 16.7 mM glucose.
resultsCoincubation of islets with vitamin D (10 nM) and 11.1 mM glucose increased islet insulin release (37.27 ± 3.75 vs. 24.64 ± 2.83 ng/islet/24 hours; P < 0.05), while vitamin D (1 and 10 nM) decreased insulin release in the presence of 16.7 mM glucose (21.14 ± 3.58 and 18.65 ± 3.84 vs. 37.71 ± 4.63 ng/ islet/24 hours; P < 0.05). Islets preincubation with vitamin D (1 and 10 nM) increased GSIS in the presence of 16.7 mM glucose (4.39 ± 0.73 and 4.39 ± 0.63 vs. 2.07 ± 0.43 ng/islet/1 hour; P < 0.05).
conclusionsPreincubation of islets with vitamin D increased GSIS but decreased insulin release in coincubation with high levels of glucose. Insulin secretion from β cells in the presence of glucose seems to be related to the dosage of vitamin D and duration of preincubation.
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