Evidence map›Paper›PMID 25745452›Full record

ArticleNeural regeneration research2012

Role of 5-hydroxytryptamine expression in cerebellar Purkinje cells in obstructive sleep apnea syndrome.

Liping Peng, Jinghua Wang, Lihong Zhang, Pan Liu, Min Wang, Min Huang, Shengnan Liu, Pingping He, Li Cui, Mingxian Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Liping PengDepartment of Pneumology, First Affiliated Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Jinghua WangDepartment of Pneumology, First Affiliated Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Lihong ZhangKey Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130021, Jilin Province, China.
Pan LiuDepartment of Pneumology, First Affiliated Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Min WangDepartment of Pneumology, First Affiliated Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Min HuangDepartment of Physiology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, Jilin Province, China.
Shengnan LiuDepartment of Pneumology, First Affiliated Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Pingping HeDepartment of Pneumology, First Affiliated Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Li CuiDepartment of Neurology, First Affiliated Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Mingxian LiDepartment of Pneumology, First Affiliated Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Shao WangKey Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130021, Jilin Province, China.
Jilin University · CNFirst Bethune Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present study, electrical stimulation to the rat insular cortex induced apnea or respiratory disturbance, reduced amplitude of genioglossal electromyogram, and decreased electromyogram integrals. In addition, arterial blood gas analysis showed arterial blood acidosis, reduced pH values, increased alkali reserve negative values, decreased peripheral blood 5-hydroxytryptamine content, and increased 5-hydroxytryptamine expression in cerebellar Purkinje cells. Following lidocaine injection to block the habenular nucleus, abnormalities in breath, genioglossal electromyogram, and blood gas values disappeared, and peripheral blood 5-hydroxytryptamine content returned to levels prior to electric stimulation. However, 5-hydroxytryptamine expression in cerebellar Purkinje cells remained high. The results suggested that 5-hydroxytryptamine expression in Purkinje cells did not correlate with ventilation function involving insular cortex and habenular nucleus.

Indexed as

5-hydroxytryptaminecerebellumhabenular nucleusinsular cortexobstructivePurkinje cellssleep apnea

Identifiers

PMID25745452
PMCPMC4346986
OpenAlexW1232237282

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.