ArticleFrontiers in neuroscience2015
Cortical reorganization in recent-onset tinnitus patients by the Heidelberg Model of Music Therapy.
Article in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- A Multimodal Meta-Analysis of Structural and Functional Changes in the Brain of Tinnitus.Frontiers in human neuroscience · 2020Pooled it
- Reporting quality of music intervention research in healthcare: A systematic review.Complementary therapies in medicine · 2018Pooled it
- A methodological assessment of studies that use voxel-based morphometry to study neural changes in tinnitus patients.Hearing research · 2017Pooled it
- Music Therapy and Tinnitus Treatment: Systematic Review and Meta-Analysis.International archives of otorhinolaryngology · 2026Review
- Review and Perspective on Brain Bases of Tinnitus.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- Pink noise: a potential sound therapy for tinnitus.American journal of translational research · 2023Article
- The Short and Long-Term Effect of Sound Therapy on Visual Attention in Chronic Tinnitus Patients.Audiology research · 2022Article
- Tinnitus Perception in Light of a Parietal Operculo-Insular Involvement: A Review.Brain sciences · 2022Review
- Outcomes at 6 months are related to brain structural and white matter microstructural reorganization in idiopathic tinnitus patients treated with sound therapy.Human brain mapping · 2021Article
- [Mechanism and research progresses of personalized music in the treatment of tinnitus].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021Article
- Cortical Thickness Alterations in Patients With Tinnitus Before and After Sound Therapy: A Surface-Based Morphometry Study.Frontiers in neuroscience · 2021Article
- Sense and Sensibility: A Review of the Behavioral Neuroscience of Tinnitus Sound Therapy and a New Typology.Current topics in behavioral neurosciences · 2021Review
- Brain Structural and Functional Reorganization in Tinnitus Patients Without Hearing Loss After Sound Therapy: A Preliminary Longitudinal Study.Frontiers in neuroscience · 2021Article
- Altered functional connectivity of the thalamus in tinnitus patients is correlated with symptom alleviation after sound therapy.Brain imaging and behavior · 2020Article
- Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Voxel-Based Morphometry Study.Frontiers in neuroscience · 2020Article
- The effects of sound therapy in tinnitus are characterized by altered limbic and auditory networks.Brain communications · 2020Article
- Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Combined VBM and SCN Study.Frontiers in human neuroscience · 2020Article
- Baseline Functional Connectivity Features of Neural Network Nodes Can Predict Improvement After Sound Therapy Through Adjusted Narrow Band Noise in Tinnitus Patients.Frontiers in neuroscience · 2019Article
- Neuroanatomical Alterations in Patients with Early Stage of Unilateral Pulsatile Tinnitus: A Voxel-Based Morphometry Study.Neural plasticity · 2018Article
- Heidelberg Neuro-Music Therapy Enhances Task-Negative Activity in Tinnitus Patients.Frontiers in neuroscience · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathophysiology and treatment of tinnitus still are fields of intensive research. The neuroscientifically motivated Heidelberg Model of Music Therapy, previously developed by the German Center for Music Therapy Research, Heidelberg, Germany, was applied to explore its effects on individual distress and on brain structures. This therapy is a compact and fast application of nine consecutive 50-min sessions of individualized therapy implemented over 1 week. Clinical improvement and long-term effects over several years have previously been published. However, the underlying neural basis of the therapy's success has not yet been explored. In the current study, the therapy was applied to acute tinnitus patients (TG) and healthy active controls (AC). Non-treated patients were also included as passive controls (PTC). As predicted, the therapeutic intervention led to a significant decrease of tinnitus-related distress in TG compared to PTC. Before and after the study week, high-resolution MRT scans were obtained for each subject. Assessment by repeated measures design for several groups (Two-Way ANOVA) revealed structural gray matter (GM) increase in TG compared to PTC, comprising clusters in precuneus, medial superior frontal areas, and in the auditory cortex. This pattern was further applied as mask for general GM changes as induced by the therapy week. The therapy-like procedure in AC also elicited similar GM increases in precuneus and frontal regions. Comparison between structural effects in TG vs. AC was calculated within the mask for general GM changes to obtain specific effects in tinnitus patients, yielding GM increase in right Heschl's gyrus, right Rolandic operculum, and medial superior frontal regions. In line with recent findings on the crucial role of the auditory cortex in maintaining tinnitus-related distress, a causative relation between the therapy-related GM alterations in auditory areas and the long-lasting therapy effects can be assumed.
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