ArticleBMC clinical pathology2015
SOD2 immunoexpression predicts lymph node metastasis in penile cancer.
Article in BMC clinical pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Association between Human Papillomavirus and Non-cervical Genital Cancers in Brazil: A Systematic Review and Meta-AnalysisAsian Pacific journal of cancer prevention : APJCP · 2018Pooled it
- Prognostic predictors of lymph node metastasis in penile cancer: a systematic review.International braz j urol : official journal of the Brazilian Society of UrologyPooled it
- Mitochondrial antioxidant enzyme (SOD2) at the crossroads of redox signaling and cancer progression.Free radical research · 2026Review
- Increased Expression of Superoxide Dismutase 2 Is an Indicator of Worse Prognosis of Oropharyngeal Cancer.International journal of molecular sciences · 2025Article
- Factors predictive of recurrence, metastasis and death in node-negative penile squamous cell carcinoma: A retrospective multicentre cohort study.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Article
- High Levels of Superoxide Dismutase 2 Are Associated With Worse Prognosis in Patients With Breast Cancer.European journal of breast health · 2024Article
- Anoikis patterns via machine learning strategy and experimental verification exhibit distinct prognostic and immune landscapes in melanoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024Article
- TLR4 and SARM1 modulate survival and chemoresistance in an HPV-positive cervical cancer cell line.Scientific reports · 2022Article
- High Expression of SOD2 Protein Is a Strong Prognostic Factor for Stage IIIB Squamous Cell Cervical Carcinoma.Antioxidants (Basel, Switzerland) · 2021Article
- Penile Cancer-Derived Cells Molecularly Characterized as Models to Guide Targeted Therapies.Cells · 2021Article
- Corpora Cavernos invasion vs. Corpus Spongiosum invasion in Penile Cancer: A systematic review and meta-analysis.Journal of Cancer · 2021Article
- Predictors of inguinal lymph node metastasis in penile cancer patients: a meta-analysis of retrospective studies.Cancer management and research · 2019Article
- Oxidative stress: therapeutic approaches for cervical cancer treatment.Clinics (Sao Paulo, Brazil) · 2018Review
- Nuclear loss and cytoplasmic expression of androgen receptor in penile carcinomas: role as a driver event and as a prognosis factor.Virchows Archiv : an international journal of pathology · 2018Article
- Alterations in Sod2-Induced Oxidative Stress Affect Endocrine Cancer Progression.The Journal of clinical endocrinology and metabolism · 2018Article
- Oxidative stress in female cancers.Oncotarget · 2018Review
- Strong SOD2 expression and HPV-16/18 positivity are independent events in cervical cancer.Oncotarget · 2018Article
- Mitochondrial ROS control of cancer.Seminars in cancer biology · 2017Review
- Mitochondrial common deletion is elevated in blood of breast cancer patients mediated by oxidative stress.Mitochondrion · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSuperoxide dismutase-2 (SOD2) is considered one of the most important antioxidant enzymes that regulate cellular redox state in normal and tumorigenic cells. Overexpression of this enzyme in lung, gastric, colorectal, breast cancer and cervical cancer malignant tumors has been observed. Its relationship with inguinal lymph node metastasis in penile cancer is unknown.
methodsSOD2 protein expression levels were determined by immunohistochemistry in 125 usual type squamous cell carcinomas of the penis from a Brazilian cancer center. The casuistic has been characterized by means of descriptive statistics. An exploratory logistic regression has been proposed to evaluate the independent predictive factors of lymph node metastasis.
resultsSOD2 expression in more than 50% of cells was observed in 44.8% of primary penile carcinomas of the usual type. This expression pattern was associated with lymph node metastasis both in the uni and multivariate analysis.
conclusionsOur results indicate that SOD2 expression predicts regional lymph node metastasis. The potential clinical implication of this observation warrants further studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.