Evidence map›Paper›PMID 25745182›Full record

ArticleBlood2015

Defective platelet autocrine signaling in HPS.

Brian Storrie

Open access · bronzeAbstract readComment
In one paragraph

Article in Blood, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Brian StorrieUNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES.ORCID http://orcid.org/0000-0002-4644-2504
University of Arkansas for Medical Sciences · US

Funding

Structure/Function Determinants of Platelet Granule SecretionR01HL119393 · NHLBI · UNIV OF ARKANSAS FOR MED SCIS · PI STORRIE, BRIAN · 2013 to 2016
$1.4M
NHLBI NIH HHS R01 HL119393
6 · The paper itself

Abstract

In this issue of Blood, Meng et al and Sharda et al use the Hermansky-Pudlak syndrome (HPS) as a model to show that adenosine 5′-diphosphate (ADP) released by dense granules serves as an autocrine signal to potentiate platelet release of α-granule and lysosome cargo and protein disulfide isomerase (PDI), all of which serve to stabilize thrombus formation.

Indexed as

AnimalsBlood PlateletsEndothelial CellsFemaleHermanski-Pudlak SyndromeHumansMaleProtein Disulfide-IsomerasesThrombosisProtein Disulfide-Isomerases

Identifiers

PMID25745182
PMCPMC4351501
OpenAlexW2005015421

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.