ReviewThe Biological bulletin2015
Calcium: amplitude, duration, or location?
Review in The Biological bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed.
- A 3D Human Neuron-on-Chip Platform to Monitor Neuronal Injury Responses.Advanced healthcare materials · 2026Article
- Article
- Enhancement of calcium responses by KJournal of biosciences · 2026Article
- Behavioral Timescale Synaptic Plasticity: A Burst in the Field of Learning and Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Investigation of the heterogeneity of cancer cells using single cell CaCell communication and signaling : CCS · 2025Article
- Abnormal calcium activity and CREB phosphorylation are associated with motor memory impairment in presenilin-1 mutant knock-in mice.Cell calcium · 2025Article
- A generalized mathematical framework for the calcium control hypothesis describes weight-dependent synaptic plasticity.Journal of computational neuroscience · 2025Article
- The calcitron: A simple neuron model that implements many learning rules via the calcium control hypothesis.PLoS computational biology · 2025Article
- Annexin- and calcium-regulated priming of legume root cells for endosymbiotic infection.Nature communications · 2024Article
- Deep-prior ODEs augment fluorescence imaging with chemical sensors.Nature communications · 2024Article
- Competitive processes shape multi-synapse plasticity along dendritic segments.Nature communications · 2024Article
- Nanofluidic logic with mechano-ionic memristive switches.Nature electronics · 2024Article
- Heterosynaptic plasticity-induced modulation of synapses.The journal of physiological sciences : JPS · 2023Review
- Making time and space for calcium control of neuron activity.Current opinion in neurobiology · 2023Review
- AAV-compatible optogenetic tools for activating endogenous calcium channels in vivo.Molecular brain · 2023Article
- Asymmetric Voltage Attenuation in Dendrites Can Enable Hierarchical Heterosynaptic Plasticity.eNeuro · 2023Article
- Pharmacological Potential of 3-Benzazepines in NMDAR-Linked Pathophysiological Processes.Biomedicines · 2023Review
- Review
- Target cell-specific plasticity rules of NMDA receptor-mediated synaptic transmission in the hippocampus.Frontiers in cellular neuroscience · 2023Article
- Recording plasticity in neuronal activity in the rodent intrinsic cardiac nervous system using calcium imaging techniques.Frontiers in synaptic neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Calcium plays a role in long-term plasticity by triggering postsynaptic signaling pathways for both the strengthening (LTP) and weakening (LTD) of synapses. Since these are opposing processes, several hypotheses have been developed to explain how calcium can trigger LTP in some situations and LTD in others. These hypotheses fall broadly into three categories, based on the amplitude of calcium concentration, the duration of the calcium elevation, and the location of the calcium influx. Here we review the experimental evidence for and against each of these hypotheses and the recent computational models utilizing each. We argue that with new experimental techniques for the precise visualization of calcium and new computational techniques for the modeling of calcium diffusion, it is time to take a new look at the location hypothesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.