Evidence map›Paper›PMID 25745063›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2015

Deficiency of Endogenous Acute-Phase Serum Amyloid A Protects apoE-/- Mice From Angiotensin II-Induced Abdominal Aortic Aneurysm Formation.

Nancy R Webb, Maria C De Beer, Joanne M Wroblewski, Ailing Ji, William Bailey, Preetha Shridas, Richard J Charnigo, Victoria P Noffsinger, Jassir Witta, Deborah A Howatt and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Serum amyloid A in HFpEF and cardiometabolic diseases.Basic research in cardiology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Serum Amyloid A: A Double-Edged Sword in Health and Disease.International journal of molecular sciences · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Advanced Research of Abdominal Aortic Aneurysms on Metabolism.Frontiers in cardiovascular medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 2 countries.

Nancy R WebbFrom the Departments of Pharmacology Division of Nutritional Sciences (N.R.W.), Physiology (M.C.D.B.) and Internal Medicine (J.M.W., A.J., W.B., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Saha Cardiovascular Research Center (N.R.W., M.C.D.B., J.M.W., A.J., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Departments of Statistics and Biostatistics (R.J.C.), University of Kentucky, Lexington; and Foundation Gastroenterology, Nashua, NH (J.W.). nrwebb1@uky.edu.
Maria C De BeerFrom the Departments of Pharmacology Division of Nutritional Sciences (N.R.W.), Physiology (M.C.D.B.) and Internal Medicine (J.M.W., A.J., W.B., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Saha Cardiovascular Research Center (N.R.W., M.C.D.B., J.M.W., A.J., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Departments of Statistics and Biostatistics (R.J.C.), University of Kentucky, Lexington; and Foundation Gastroenterology, Nashua, NH (J.W.).
Joanne M WroblewskiFrom the Departments of Pharmacology Division of Nutritional Sciences (N.R.W.), Physiology (M.C.D.B.) and Internal Medicine (J.M.W., A.J., W.B., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Saha Cardiovascular Research Center (N.R.W., M.C.D.B., J.M.W., A.J., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Departments of Statistics and Biostatistics (R.J.C.), University of Kentucky, Lexington; and Foundation Gastroenterology, Nashua, NH (J.W.).
Ailing JiFrom the Departments of Pharmacology Division of Nutritional Sciences (N.R.W.), Physiology (M.C.D.B.) and Internal Medicine (J.M.W., A.J., W.B., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Saha Cardiovascular Research Center (N.R.W., M.C.D.B., J.M.W., A.J., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Departments of Statistics and Biostatistics (R.J.C.), University of Kentucky, Lexington; and Foundation Gastroenterology, Nashua, NH (J.W.).
William BaileyFrom the Departments of Pharmacology Division of Nutritional Sciences (N.R.W.), Physiology (M.C.D.B.) and Internal Medicine (J.M.W., A.J., W.B., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Saha Cardiovascular Research Center (N.R.W., M.C.D.B., J.M.W., A.J., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Departments of Statistics and Biostatistics (R.J.C.), University of Kentucky, Lexington; and Foundation Gastroenterology, Nashua, NH (J.W.).
Preetha ShridasFrom the Departments of Pharmacology Division of Nutritional Sciences (N.R.W.), Physiology (M.C.D.B.) and Internal Medicine (J.M.W., A.J., W.B., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Saha Cardiovascular Research Center (N.R.W., M.C.D.B., J.M.W., A.J., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Departments of Statistics and Biostatistics (R.J.C.), University of Kentucky, Lexington; and Foundation Gastroenterology, Nashua, NH (J.W.).
Richard J CharnigoFrom the Departments of Pharmacology Division of Nutritional Sciences (N.R.W.), Physiology (M.C.D.B.) and Internal Medicine (J.M.W., A.J., W.B., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Saha Cardiovascular Research Center (N.R.W., M.C.D.B., J.M.W., A.J., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Departments of Statistics and Biostatistics (R.J.C.), University of Kentucky, Lexington; and Foundation Gastroenterology, Nashua, NH (J.W.).
Victoria P NoffsingerFrom the Departments of Pharmacology Division of Nutritional Sciences (N.R.W.), Physiology (M.C.D.B.) and Internal Medicine (J.M.W., A.J., W.B., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Saha Cardiovascular Research Center (N.R.W., M.C.D.B., J.M.W., A.J., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Departments of Statistics and Biostatistics (R.J.C.), University of Kentucky, Lexington; and Foundation Gastroenterology, Nashua, NH (J.W.).
Jassir WittaFrom the Departments of Pharmacology Division of Nutritional Sciences (N.R.W.), Physiology (M.C.D.B.) and Internal Medicine (J.M.W., A.J., W.B., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Saha Cardiovascular Research Center (N.R.W., M.C.D.B., J.M.W., A.J., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Departments of Statistics and Biostatistics (R.J.C.), University of Kentucky, Lexington; and Foundation Gastroenterology, Nashua, NH (J.W.).
Deborah A HowattFrom the Departments of Pharmacology Division of Nutritional Sciences (N.R.W.), Physiology (M.C.D.B.) and Internal Medicine (J.M.W., A.J., W.B., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Saha Cardiovascular Research Center (N.R.W., M.C.D.B., J.M.W., A.J., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Departments of Statistics and Biostatistics (R.J.C.), University of Kentucky, Lexington; and Foundation Gastroenterology, Nashua, NH (J.W.).
Anju BalakrishnanFrom the Departments of Pharmacology Division of Nutritional Sciences (N.R.W.), Physiology (M.C.D.B.) and Internal Medicine (J.M.W., A.J., W.B., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Saha Cardiovascular Research Center (N.R.W., M.C.D.B., J.M.W., A.J., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Departments of Statistics and Biostatistics (R.J.C.), University of Kentucky, Lexington; and Foundation Gastroenterology, Nashua, NH (J.W.).
Debra L RateriFrom the Departments of Pharmacology Division of Nutritional Sciences (N.R.W.), Physiology (M.C.D.B.) and Internal Medicine (J.M.W., A.J., W.B., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Saha Cardiovascular Research Center (N.R.W., M.C.D.B., J.M.W., A.J., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Departments of Statistics and Biostatistics (R.J.C.), University of Kentucky, Lexington; and Foundation Gastroenterology, Nashua, NH (J.W.).
Alan DaughertyFrom the Departments of Pharmacology Division of Nutritional Sciences (N.R.W.), Physiology (M.C.D.B.) and Internal Medicine (J.M.W., A.J., W.B., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Saha Cardiovascular Research Center (N.R.W., M.C.D.B., J.M.W., A.J., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Departments of Statistics and Biostatistics (R.J.C.), University of Kentucky, Lexington; and Foundation Gastroenterology, Nashua, NH (J.W.).
Frederick C De BeerFrom the Departments of Pharmacology Division of Nutritional Sciences (N.R.W.), Physiology (M.C.D.B.) and Internal Medicine (J.M.W., A.J., W.B., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Saha Cardiovascular Research Center (N.R.W., M.C.D.B., J.M.W., A.J., P.S., V.P.N., D.A.H., A.B., D.L.R., A.D., F.C.D.B.), and Departments of Statistics and Biostatistics (R.J.C.), University of Kentucky, Lexington; and Foundation Gastroenterology, Nashua, NH (J.W.).
DSM (Netherlands) · NL

Funding

The role of IKKß in linking obesity to adipose tissue inflammation and adipogeneP20GM103527 · NIGMS · UNIVERSITY OF KENTUCKY · PI MORRIS, ANDREW J · 2012 to 2017
$13.7M
THROMBOSPONDIN1 MEDIATES MACROPHAGE INFILTRATION INTO ADIPOSE TISSUE AND PROMOTEP20RR021954 · NCRR · UNIVERSITY OF KENTUCKY · PI CASSIS, LISA A · 2008 to 2011
$8.3M
Specific Secretory Phospholipase A2 Isozymes Promote Aneurysm FormationP01HL080100 · NHLBI · UNIVERSITY OF KENTUCKY · PI DAUGHERTY, ALAN · 2006 to 2010
$8.2M
Mouse CoreP01HL086670 · NHLBI · UNIVERSITY OF KENTUCKY · PI RATERI, DEBRA · 2007 to 2011
$7.1M
NCRR NIH HHS P20 RR021954NHLBI NIH HHS P01 HL080100NHLBI NIH HHS P01 HL086670NHLBI NIH HHS P01HL086670NIGMS NIH HHS P20 GM103527
6 · The paper itself

Abstract

objectiveRupture of abdominal aortic aneurysm (AAA), a major cause of death in the aged population, is characterized by vascular inflammation and matrix degradation. Serum amyloid A (SAA), an acute-phase reactant linked to inflammation and matrix metalloproteinase induction, correlates with aortic dimensions before aneurysm formation in humans. We investigated whether SAA deficiency in mice affects AAA formation during angiotensin II (Ang II) infusion. APPROACH AND

resultsPlasma SAA increased ≈60-fold in apoE(-/-) mice 24 hours after intraperitoneal Ang II injection (100 μg/kg; n=4) and ≈15-fold after chronic 28-day Ang II infusion (1000 ng/kg per minute; n=9). AAA incidence and severity after 28-day Ang II infusion was significantly reduced in apoE(-/-) mice lacking both acute-phase SAA isoforms (SAAKO; n=20) compared with apoE(-/-) mice (SAAWT; n=20) as assessed by in vivo ultrasound and ex vivo morphometric analyses, despite a significant increase in systolic blood pressure in SAAKO mice compared with SAAWT mice after Ang II infusion. Atherosclerotic lesion area of the aortic arch was similar in SAAKO and SAAWT mice after 28-day Ang II infusion. Immunostaining detected SAA in AAA tissues of Ang II-infused SAAWT mice that colocalized with macrophages, elastin breaks, and enhanced matrix metalloproteinase activity. Matrix metalloproteinase-2 activity was significantly lower in aortas of SAAKO mice compared with SAAWT mice after 10-day Ang II infusion.

conclusionsLack of endogenous acute-phase SAA protects against experimental AAA through a mechanism that may involve reduced matrix metalloproteinase-2 activity.

Indexed as

Angiotensin IIAnimalsAortic Aneurysm, AbdominalApolipoproteins EBiomarkersDisease Models, AnimalElastinMacrophagesMatrix Metalloproteinase 2MiceMice, Inbred C57BLMice, KnockoutRandom AllocationSensitivity and SpecificitySerum Amyloid A ProteinAngiotensin IIApolipoproteins EBiomarkersElastinMatrix Metalloproteinase 2Serum Amyloid A Proteinacute-phase proteinsaneurysminflammationserum amyloid A protein

Identifiers

PMID25745063
PMCPMC4823018
OpenAlexW1981440298

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.