ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2016
A Novel Analytic Technique to Measure Associations Between Circulating Biomarkers and Physical Performance Across the Adult Life Span.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Pooled it
- A High Omega-3 Fatty Acid Multinutrient Supplement Benefits Cognition and Mobility in Older Women: A Randomized, Double-blind, Placebo-controlled Pilot Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Trial
- Inflammaging and the sex-frailty paradox.Aging clinical and experimental research · 2025Article
- Role of protein intake in maintaining muscle mass composition among elderly females suffering from sarcopenia.Frontiers in nutrition · 2025Article
- Plasma proteomic signature of human longevity.Aging cell · 2024Article
- Association of inflammatory markers with muscle and cognitive function in early and late-aging older adults.The journal of nutrition, health & aging · 2024Article
- A molecular index for biological age identified from the metabolome and senescence-associated secretome in humans.Aging cell · 2024Article
- Association between aging-related biomarkers and longitudinal trajectories of intrinsic capacity in older adults.GeroScience · 2023Article
- Multisystem physiological perspective of human frailty and its modulation by physical activity.Physiological reviews · 2023Review
- Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Brain age and other bodily 'ages': implications for neuropsychiatry.Molecular psychiatry · 2019Review
- Interleukin-6 and lipoprotein-associated phospholipase A2 are associated with functional trajectories.PloS one · 2019Article
- Combined Inflammation and Metabolism Biomarker Indices of Robust and Impaired Physical Function in Older Adults.Journal of the American Geriatrics Society · 2018Article
- Relationships Between Markers of Inflammation and Muscle Mass, Strength and Function: Findings from the Hertfordshire Cohort Study.Calcified tissue international · 2018Article
- Systemic Inflammation in the Recovery Stage of Stroke: Its Association with Sarcopenia and Poor Functional Rehabilitation Outcomes.Progress in rehabilitation medicine · 2018Article
- Clinical Fractures Among Older Men With Diabetes Are Mediated by Diabetic Complications.The Journal of clinical endocrinology and metabolism · 2018Article
- Association of pre-chemotherapy peripheral blood pro-inflammatory and coagulation factors with reduced relative dose intensity in women with breast cancer.Breast cancer research : BCR · 2017Article
- Association Between Serum Tumor Necrosis Factor Receptor 1 and Trajectories of Functional Status: The Northern Manhattan Study.American journal of epidemiology · 2017Article
- Biomarker signatures of aging.Aging cell · 2017Article
- Systemic inflammation, body composition, and physical performance in old community-dwellers.Journal of cachexia, sarcopenia and muscle · 2017Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Understanding associations between circulating biomarkers and physical performance across the adult life span could aid in better describing mechanistic pathways leading to disability. We hypothesized that high concentrations of circulating biomarkers would be associated with lower functioning across study populations representing the adult life span. The data were from four intervention and two observational studies with ages ranging 22-89 years. Biomarkers assayed included inflammatory, coagulation, and endothelial function markers. Physical performance was measured either by VO2peak (studies of young and middle-aged adults) or usual gait speed (studies of older adults). Partialled (by age, body mass index, race, and sex) and weighted common correlations were calculated between biomarkers and physical performance. Homogeneity of the associations was also assessed. Interleukin-6 (weighted r = -.22), tumor necrosis factor receptor 2 (weighted r = -.19), D-dimer (weighted r = -.16), tumor necrosis factor receptor 1 (weighted r = -.15), granulocyte colony-stimulating factor (weighted r = -.14), and tumor necrosis factor alpha (weighted r = -.10) were all significantly inversely correlated with physical performance (p < .05). All significant correlations were homogeneous across studies. In summary, we observed consistent inverse associations between six circulating biomarkers and objective measures of physical performance. These results suggest that these serum biomarkers may be broadly applicable for detection, trajectory, and treatment monitoring of physical function across the life span or possibly for midlife predictors of functionally deleterious conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.