Evidence map›Paper›PMID 25745020›Full record

ArticleJournal of the National Cancer Institute2015

The contributions of breast density and common genetic variation to breast cancer risk.

Celine M Vachon, V Shane Pankratz, Christopher G Scott, Lothar Haeberle, Elad Ziv, Matthew R Jensen, Kathleen R Brandt, Dana H Whaley, Janet E Olson, Katharina Heusinger and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the National Cancer Institute, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Breastfeeding and breast cancer risk by receptor status--a systematic review and meta-analysis.Annals of oncology : official journal of the European Society for Medical Oncology · 2015
    Pooled it
  3. Trial
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  14. Extending the Breast Cancer Surveillance Consortium Model of Invasive Breast Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Article
  15. Review
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49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Celine M VachonAffiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF). vachon.celine@mayo.edu.
V Shane PankratzAffiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Christopher G ScottAffiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Lothar HaeberleAffiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Elad ZivAffiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Matthew R JensenAffiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Kathleen R BrandtAffiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Dana H WhaleyAffiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Janet E OlsonAffiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Katharina HeusingerAffiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Carolin C HackAffiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Sebastian M JudAffiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Matthias W BeckmannAffiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Ruediger Schulz-WendtlandAffiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Jeffrey A TiceAffiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Aaron D NormanAffiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Julie M CunninghamAffiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Kristen S PurringtonAffiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Douglas F EastonAffiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Thomas A SellersAffiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Karla KerlikowskeAffiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Peter A FaschingAffiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Fergus J CouchAffiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3M
Risk-based Imaging Strategies to Improve Breast Cancer Surveillance OutcomesP01CA154292 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Janie M Lee · 2011 to 2026
$52.9M
The Role of CHFR in Tumorigenesis and Paclitaxel-Sensitivity in Breast CancerP50CA116201 · NCI · MAYO CLINIC ROCHESTER · PI PETER C LUCAS · 2005 to 2026
$49.9M
A genome-wide association study for breast cancer in BRCA1 mutation carriersR01CA128978 · NCI · MAYO CLINIC ROCHESTER · PI COUCH, FERGUS JOSEPH · 2008 to 2012
$4.8M
A Mayo Cohort Study of Mammographic Breast DensityR01CA097396 · NCI · MAYO CLINIC ROCHESTER · PI VACHON, CELINE M · 2003 to 2007
$3.1M
Identifying Genes for Mammographic Breast DensityR01CA128931 · NCI · MAYO CLINIC ROCHESTER · PI VACHON, CELINE M · 2008 to 2012
$2.7M
Risk factors for breast cancer molecular subtypesR01CA140286 · NCI · MAYO CLINIC ROCHESTER · PI KERLIKOWSKE, KARLA M, VACHON, CELINE M · 2010 to 2014
$2.6M
Genetics of mammographic density and breast cancer risk in LatinasK24CA169004 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZIV, ELAD · 2012 to 2021
$1.8M
Genetics of Mammographic Density in Ashkenazi JewsR21CA179442 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZIV, ELAD · 2013 to 2014
$366k
Cancer Research UK 16563NCI NIH HHS CA15083NCI NIH HHS K24 CA169004NCI NIH HHS P01 CA154292NCI NIH HHS P30 CA015083NCI NIH HHS P50 CA116201NCI NIH HHS R01 CA097396NCI NIH HHS R01 CA128931NCI NIH HHS R01 CA128978NCI NIH HHS R01CA140286NCI NIH HHS R01CA240386NCI NIH HHS R01 CA97396NCI NIH HHS R21 CA179442
6 · The paper itself

Abstract

We evaluated whether a 76-locus polygenic risk score (PRS) and Breast Imaging Reporting and Data System (BI-RADS) breast density were independent risk factors within three studies (1643 case patients, 2397 control patients) using logistic regression models. We incorporated the PRS odds ratio (OR) into the Breast Cancer Surveillance Consortium (BCSC) risk-prediction model while accounting for its attributable risk and compared five-year absolute risk predictions between models using area under the curve (AUC) statistics. All statistical tests were two-sided. BI-RADS density and PRS were independent risk factors across all three studies (P interaction = .23). Relative to those with scattered fibroglandular densities and average PRS (2(nd) quartile), women with extreme density and highest quartile PRS had 2.7-fold (95% confidence interval [CI] = 1.74 to 4.12) increased risk, while those with low density and PRS had reduced risk (OR = 0.30, 95% CI = 0.18 to 0.51). PRS added independent information (P < .001) to the BCSC model and improved discriminatory accuracy from AUC = 0.66 to AUC = 0.69. Although the BCSC-PRS model was well calibrated in case-control data, independent cohort data are needed to test calibration in the general population.

Indexed as

Polymorphism, Single NucleotideAdultAgedArea Under CurveBreastBreast DensityBreast NeoplasmsCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenetic VariationGermanyHumansLogistic ModelsMammary Glands, HumanMiddle Aged

Identifiers

PMID25745020
PMCPMC4598340

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