ArticleInvestigative ophthalmology & visual science2015
Biogeographic Ancestry in the African Descent and Glaucoma Evaluation Study (ADAGES): Association With Corneal and Optic Nerve Structure.
Article in Investigative ophthalmology & visual science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00221923 (African Descent and Glaucoma Evaluation Study), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
African Descent and Glaucoma Evaluation Study (Formerly African Americans With Glaucoma Study)
Who cites it
19 citing papers in PubMed.
- Ocular Hypertension Treatment Study: Effect of Time After Incident Glaucoma on OCT Optic Nerve Head and Macula Measurements.American journal of ophthalmology · 2026Article
- Visual Field Progression Rate and Laminar Depth and Curvature in the African Descent and Glaucoma Evaluation Study (ADAGES).Translational vision science & technology · 2026Article
- Glaucomatous Remodeling of the Lamina Cribrosa: Association With Visual Field Progression.Investigative ophthalmology & visual science · 2026Article
- Glaucoma Progression Detection Time Using OCT and OCTA in African and European Descendants.American journal of ophthalmology · 2026Article
- Understanding Glaucoma: Why it Remains a Leading Cause of Blindness Worldwide.Klinische Monatsblatter fur Augenheilkunde · 2025Review
- Article
- Social determinants associated with loss of an eye in the United States using theOrbit (Amsterdam, Netherlands) · 2022Article
- Racial Differences in the Rate of Change in Anterior Lamina Cribrosa Surface Depth in the African Descent and Glaucoma Evaluation Study.Investigative ophthalmology & visual science · 2021Article
- The Role of Genetic Ancestry as a Risk Factor for Primary Open-angle Glaucoma in African Americans.Investigative ophthalmology & visual science · 2021Article
- Long-Term Follow-Up of Normal Tension Glaucoma Patients With TBK1 Gene Mutations in One Large Pedigree.American journal of ophthalmology · 2020Article
- Racial Differences in the Association of Anterior Lamina Cribrosa Surface Depth and Glaucoma Severity in the African Descent and Glaucoma Evaluation Study (ADAGES).Investigative ophthalmology & visual science · 2019Article
- The African Descent and Glaucoma Evaluation Study (ADAGES) III: Contribution of Genotype to Glaucoma Phenotype in African Americans: Study Design and Baseline Data.Ophthalmology · 2019Article
- Racial Differences in Rate of Change of Spectral-Domain Optical Coherence Tomography-Measured Minimum Rim Width and Retinal Nerve Fiber Layer Thickness.American journal of ophthalmology · 2018Article
- Detection of Glaucoma Progression in Individuals of African Descent Compared With Those of European Descent.JAMA ophthalmology · 2018Observational
- Rate and Pattern of Rim Area Loss in Healthy and Progressing Glaucoma Eyes.Ophthalmology · 2016Article
- African Ancestry Is Associated with Higher Intraocular Pressure in Latinos.Ophthalmology · 2016Article
- Quantitative Trait Locus Analysis of SIX1-SIX6 With Retinal Nerve Fiber Layer Thickness in Individuals of European Descent.American journal of ophthalmology · 2015Observational
- Optic Disc Size and Circumpapillary Retinal Nerve Fiber Layer Thinning in Glaucoma.Ophthalmology. GlaucomaObservational
- Comparison of Peripapillary Capillary Density in Glaucoma Patients of African and European Descent.Ophthalmology. GlaucomaObservational
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
purposeWe determined if quantitative measurements of biogeographic ancestry (BGA) correlate with variations in optic disc area, corneal thickness (CCT), and retinal nerve fiber layer (RNFL) thickness.
methodsData were obtained from 656 participants in the African Descent and Glaucoma Evaluation Study (ADAGES) cohort who consented to BGA testing. Data for CCT, optic disc area, and RNFL thickness were obtained from subjects in the ADAGES study who also had participated in the current substudy. A total of 31 ancestry informative markers (AIMs) with large allele frequencies differences between populations was used to calculate admixture proportion (implemented in STRUCTURE). Correlations with BGA adjusted for diagnosis, age, and sex for CCT and optic disc area using the whole group and RNFL thickness adjusted for age and sex for the normal study participants were determined.
resultsThe mean percentage of African admixture was 79.6% in the self-described African Descent (AD) group and 3.5% in the European Descent (ED) group. Percent African ancestry was significantly correlated with CCT (ρ = -0.27, P < 0.0001) and disc area (ρ = 0.15, P < 0.0001), but only marginally associated with RNFL thickness (ρ = 0.20, P = 0.092) in adjusted models.
conclusionsThe BGA correlates with variation in ocular features that significantly differ across racial groups and that have been associated with the development of glaucoma. While BGA can provide an objective measurement of the biologic component of self-described race for ocular research, for most nongenetic epidemiologic studies, self-described race may adequately describe the associations with these ocular characteristics. (ClinicalTrials.gov number, NCT00221923.).
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