Evidence map›Paper›PMID 25744874›Full record

ArticleJournal of the American Medical Directors Association2015

Impaired Arousal in Older Adults Is Associated With Prolonged Hospital Stay and Discharge to Skilled Nursing Facility.

Andrea M Yevchak, Jin Ho Han, Kelly Doherty, Elizabeth G Archambault, Brittany Kelly, Rameela Chandrasekhar, E Wesley Ely, James L Rudolph

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Medical Directors Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Exploring Delirium's Heterogeneity: Association Between Arousal Subtypes at Initial Presentation and 6-Month Mortality in Older Emergency Department Patients.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2017
    Article
  2. Observational
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Andrea M YevchakDuquesne University, Pittsburgh, PA. Electronic address: yevchaka@duq.edu.
Jin Ho HanVanderbilt University School of Medicine and the Tennessee Valley Veteran's Affairs Geriatric Research Education and Clinical Center (GRECC), Nashville, TN.
Kelly DohertyVanderbilt University School of Medicine and the Tennessee Valley Veteran's Affairs Geriatric Research Education and Clinical Center (GRECC), Nashville, TN.
Elizabeth G ArchambaultVeterans Affairs Boston Healthcare System, Boston, MA.
Brittany KellyVeterans Affairs Boston Healthcare System, Boston, MA.
Rameela ChandrasekharVanderbilt University School of Medicine and the Tennessee Valley Veteran's Affairs Geriatric Research Education and Clinical Center (GRECC), Nashville, TN.
E Wesley ElyVanderbilt University School of Medicine and the Tennessee Valley Veteran's Affairs Geriatric Research Education and Clinical Center (GRECC), Nashville, TN.
James L RudolphVeterans Affairs Boston Healthcare System, Boston, MA; Harvard University, Cambridge, MA. Electronic address: jrudolph@partners.org.
VA Boston Healthcare System · USDuquesne University · US

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
The MIND USA StudyR01AG035117 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ELY, E WESLEY · 2011 to 2016
$7.3M
The MIND ICU StudyR01AG027472 · NIA · VANDERBILT UNIVERSITY · PI ELY, E WESLEY · 2006 to 2010
$3.0M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)TL1TR000447 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$1.2M
Delirium in the Emergency Department: Novel Screening and Natural CourseK23AG032355 · NIA · VANDERBILT UNIVERSITY · PI HAN, JIN HO · 2010 to 2014
$745k
NCATS NIH HHS 2 UL1 TR000445-06NCATS NIH HHS TL1 TR000447NCATS NIH HHS UL1 TR000445NCRR NIH HHS UL1 RR024975NCRR NIH HHS UL1 RR024975-01NIA NIH HHS K23 AG032355NIA NIH HHS K23AG032355NIA NIH HHS R01 AG027472NIA NIH HHS R01 AG035117
6 · The paper itself

Abstract

backgroundPoor cognitive function is associated with negative consequences across settings of care, but research instruments are arduous for routine clinical implementation. This study examined the association between impaired arousal, as measured using an ultra-brief screen, and risk of 2 adverse clinical outcomes: hospital length of stay and discharge to a skilled nursing facility (SNF). DESIGN, SETTING, AND

participantsA secondary data analysis was conducted using 2 separate groups of medical ward patients: a Veterans Affairs medical center in the northeast (N = 1487, between 2010 and 2012) 60 years and older and a large tertiary care, university-based medical center (N = 669, between 2007 and 2013) 65 years and older in the southeastern United States. MEASUREMENTS: The impact of impaired arousal, defined by the Richmond Agitation Sedation Scale as anything other than "awake and alert," was determined using Cox Proportional Hazard Regression for time to hospital discharge and logistic regression for discharge to a SNF. Hazard ratios (HRs) and odds ratios (OR) with their 95% confidence intervals (CI) are reported, respectively. Both models were adjusted age, sex, and dementia.

resultsThe 2156 total patients included in these groups had a mean age of 76 years, of whom 16.4% in group 1 and 28.5% in group 2 had impaired arousal. In the first group, patients with normal arousal spent an average of 5.9 days (standard deviation 6.2) in the hospital, while those with impaired arousal spent 8.5 days (9.2). On any given day, patients with impaired arousal had 27% lower chance of being discharged (adjusted HR 0.73 (95% CI 0.63-0.84). In the second group, individuals with normal arousal spent 3.8 (4.1) days in the hospital compared with 4.7 (4.6) for those with impaired arousal; indicating a 21% lower chance of being discharged [adjusted HR 0.79 (95% CI 0.66-0.95). With regard to risk of discharge to SNF, those with impaired arousal in group 1 had a 65% higher risk than those without impaired arousal [adjusted OR 1.65 (95% CI 1.21-2.25)], and those in group 2 had a nonsignificant 27% higher risk [adjusted OR 1.27 (0.80-2.03)]. Because of the quality improvement nature, this analysis did not control for comorbidities, which is a significant limitation.

conclusionsIn this study of over 2000 older hospitalized patients, the simple observation of an abnormal arousal level may be an independent predictor of a longer hospital stay and discharge to SNF.

Indexed as

ArousalLength of StayPatient DischargeSkilled Nursing FacilitiesAcademic Medical CentersAgedAged, 80 and overFemaleHumansMaleMiddle AgedProportional Hazards ModelsProspective StudiesSoutheastern United Statesacute careArousalcognitiontransitional care

Identifiers

PMID25744874
PMCPMC4668713
OpenAlexW1968936347

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.