ArticleNeuropsychologia2015
Facial emotion recognition impairments are associated with brain volume abnormalities in individuals with HIV.
Article in Neuropsychologia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A Systematic Review and Meta-Analysis of Social Cognition Among People Living with HIV: Implications for Non-Social Cognition and Social Everyday Functioning.Neuropsychology review · 2025Pooled it
- Different roles of frontal versus striatal atrophy in HIV-associated neurocognitive disorders.Human brain mapping · 2019Pooled it
- Brain Structural Changes following HIV Infection: Meta-Analysis.AJNR. American journal of neuroradiology · 2018Pooled it
- Sex-specific effects of low-dose hydrocortisone on threat detection in HIV.Journal of neurovirology · 2021Trial
- Resting-state neural signatures of depressive symptoms in acute HIV.Journal of neurovirology · 2020Trial
- Cognitive and sensorimotor impairments in virally suppressed people with and without HIV in Uganda: Associations with neurofilament light chain as a biomarker of neuronal injury.Journal of neurovirology · 2026Article
- Beyond accuracy: facial emotion perception bias in people with HIV in Uganda.Journal of neurovirology · 2026Article
- Social cognition abilities in people with HIV: the role of stigma and other factors.AIDS (London, England) · 2025Review
- Divergent structural and functional brain alterations in HIV-infected patients: a multimodal meta-analysis.Frontiers in neurology · 2025Review
- Neurological impact of HIV/AIDS and substance use alters brain function and structure.Frontiers in medicine · 2024Review
- Alexithymia Among People Living with HIV: A Scoping Review.AIDS and behavior · 2023Article
- The Evolution of Assessing Central Nervous System Complications in Human Immunodeficiency Virus: Where Do We Go From Here?The Journal of infectious diseases · 2023Article
- Effects of Early-Life Adversities on Neuropsychiatric and Executive Functions in HIV-Positive Adults.Journal of the International Neuropsychological Society : JINS · 2023Article
- Synergistic effects of high early-life stress exposure and HIV infection on reaction time variability.Frontiers in psychology · 2023Article
- Neurodegeneration Within the Amygdala Is Differentially Induced by Opioid and HIV-1 Tat Exposure.Frontiers in neuroscience · 2022Article
- HIV-1 Tat and morphine decrease murine inter-male social interactions and associated oxytocin levels in the prefrontal cortex, amygdala, and hypothalamic paraventricular nucleus.Hormones and behavior · 2021Article
- Alexithymia Predicts Carotid Atherosclerosis, Vascular Events, and All-Cause Mortality in Human Immunodeficiency Virus-Infected Patients: An Italian Multisite Prospective Cohort Study.Open forum infectious diseases · 2019Article
- HIV infection and age effects on striatal structure are additive.Journal of neurovirology · 2019Article
- Novel Machine Learning Identifies Brain Patterns Distinguishing Diagnostic Membership of Human Immunodeficiency Virus, Alcoholism, and Their Comorbidity of Individuals.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
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Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Impaired facial emotion recognition abilities in HIV+ patients are well documented, but little is known about the neural etiology of these difficulties. We examined the relation of facial emotion recognition abilities to regional brain volumes in 44 HIV-positive (HIV+) and 44 HIV-negative control (HC) adults. Volumes of structures implicated in HIV-associated neuropathology and emotion recognition were measured on MRI using an automated segmentation tool. Relative to HC, HIV+ patients demonstrated emotion recognition impairments for fearful expressions, reduced anterior cingulate cortex (ACC) volumes, and increased amygdala volumes. In the HIV+ group, fear recognition impairments correlated significantly with ACC, but not amygdala volumes. ACC reductions were also associated with lower nadir CD4 levels (i.e., greater HIV-disease severity). These findings extend our understanding of the neurobiological substrates underlying an essential social function, facial emotion recognition, in HIV+ individuals and implicate HIV-related ACC atrophy in the impairment of these abilities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.