ArticleScientific reports2015
A novel mechanism for small heat shock proteins to function as molecular chaperones.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Revisiting the Small Heat Shock Protein Family inmicroPublication biology · 2026Article
- Genome-wide profile analysis of the Hsp20 family in lettuce and identification of its response to drought stress.Frontiers in plant science · 2024Article
- A subfamily of the small heat shock proteins of the marine red alga Neopyropia yezoensis localizes in the chloroplast.Cell stress & chaperones · 2023Article
- A Review on the Involvement of Heat Shock Proteins (Extrinsic Chaperones) in Response to Stress Conditions in Aquatic Organisms.Antioxidants (Basel, Switzerland) · 2023Review
- Tardigrade small heat shock proteins can limit desiccation-induced protein aggregation.Communications biology · 2023Article
- The Common Bean Small Heat Shock Protein Nodulin 22 fromMolecules (Basel, Switzerland) · 2022Article
- Biased gene expression reveals the contribution of subgenome to altitude adaptation in allopolyploidEcology and evolution · 2022Article
- SiHSFA2e regulated expression of SisHSP21.9 maintains chloroplast proteome integrity under high temperature stress.Cellular and molecular life sciences : CMLS · 2022Article
- Short-form OPA1 is a molecular chaperone in mitochondrial intermembrane space.Science China. Life sciences · 2022Article
- Genome-wide analysis of HSP20 gene family and expression patterns under heat stress in cucumber (Frontiers in plant science · 2022Article
- Minimal Yet Powerful: The Role of Archaeal Small Heat Shock Proteins in Maintaining Protein Homeostasis.Frontiers in molecular biosciences · 2022Review
- The Pathophysiological Role of Heat Shock Response in Autoimmunity: A Literature Review.Cells · 2021Review
- Illuminating amyloid fibrils: Fluorescence-based single-molecule approaches.Computational and structural biotechnology journal · 2021Review
- Mitochondria-Targeted SmsHSP24.1 Overexpression Stimulates Early Seedling Vigor and Stress Tolerance by Multi-Pathway Transcriptome-Reprogramming.Frontiers in plant science · 2021Article
- A novel T177P missense variant in the HSPA8 gene associated with the low tolerance of Awassi sheep to heat stress.Tropical animal health and production · 2020Article
- The noncanonical small heat shock protein HSP-17 fromThe Journal of biological chemistry · 2020Article
- Article
- The Mitochondrial Small Heat Shock Protein HSP22 from Pea is a Thermosoluble Chaperone Prone to Co-Precipitate with Unfolding Client Proteins.International journal of molecular sciences · 2019Article
- It takes a dimer to tango: Oligomeric small heat shock proteins dissociate to capture substrate.The Journal of biological chemistry · 2018Article
- Transcriptome States Reflect Imaging of Aging States.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small heat shock proteins (sHSPs) are molecular chaperones ubiquitously present in all forms of life, but their function mechanisms remain controversial. Here we show by cryo-electron microscopy and single particle 3D reconstruction that, at the low temperatures (4-25°C), CeHSP17 (a sHSP from Caenorhabditis elegans) exists as a 24-subunit spherical oligomer with tetrahedral symmetry. Our studies demonstrate that CeHSP17 forms large sheet-like super-molecular assemblies (SMAs) at the high temperatures (45-60°C), and such SMAs are apparently the form that exhibits chaperone-like activity. Our findings suggest a novel molecular mechanism for sHSPs to function as molecular chaperones.
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