ArticleProceedings of the National Academy of Sciences of the United States of America1989
100-kDa polypeptides in peripheral clathrin-coated vesicles are required for receptor-mediated endocytosis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 108 citations in OpenAlex.
- A cytoplasmic motif in HLA-E that drives clathrin-mediated endocytosis and VCP-associated postendocytic trafficking.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- PEGylated versus Non-PEGylated pH-Sensitive Liposomes: New Insights from a Comparative Antitumor Activity Study.Pharmaceutics · 2022Article
- Regulation of clathrin-mediated endocytosis by hierarchical allosteric activation of AP2.The Journal of cell biology · 2017Article
- Article
- A phosphotyrosine switch for cargo sequestration at clathrin-coated buds.The Journal of biological chemistry · 2014Article
- The apoptotic engulfment protein Ced-6 participates in clathrin-mediated yolk uptake in Drosophila egg chambers.Molecular biology of the cell · 2012Article
- Cellular uptake of electron paramagnetic resonance imaging probes through endocytosis of liposomes.Biochimica et biophysica acta · 2009Article
- The AP-2 adaptor beta2 appendage scaffolds alternate cargo endocytosis.Molecular biology of the cell · 2008Article
- A novel AAK1 splice variant functions at multiple steps of the endocytic pathway.Molecular biology of the cell · 2007Article
- Internalization of large double-membrane intercellular vesicles by a clathrin-dependent endocytic process.Molecular biology of the cell · 2007Article
- Clathrin-dependent association of CVAK104 with endosomes and the trans-Golgi network.Molecular biology of the cell · 2006Article
- A single common portal for clathrin-mediated endocytosis of distinct cargo governed by cargo-selective adaptors.Molecular biology of the cell · 2006Article
- Bending a membrane: how clathrin affects budding.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis.The Journal of cell biology · 2002Article
- Dynamin-dependent transferrin receptor recycling by endosome-derived clathrin-coated vesicles.Molecular biology of the cell · 2002Article
- The role of endocytic l1 trafficking in polarized adhesion and migration of nerve growth cones.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- The role of dynamin and its binding partners in coated pit invagination and scission.The Journal of cell biology · 2001Article
- A novel clathrin homolog that co-distributes with cytoskeletal components functions in the trans-Golgi network.The EMBO journal · 2001Article
- NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis.The EMBO journal · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of the 100-kDa polypeptide components of clathrin-coated vesicles in endocytosis was investigated by microinjection of specific monoclonal antibodies. Receptor-mediated uptake of transferrin and liposomes was quantitatively inhibited. These results show that the 100-kDa polypeptides are directly involved in localized clathrin assembly at the cell periphery and are markers for the endocytic pathway. This demonstrates an in situ function of these polypeptides and the protein complexes in which they are found.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.