Evidence map›Paper›PMID 25744569›Full record

SynthesisMolecular neurobiology2016

Serum Uric Acid Levels and Outcomes After Acute Ischemic Stroke.

Zhongchao Wang, Yanlin Lin, Yuxiu Liu, Ying Chen, Bin Wang, Changgui Li, Shengli Yan, Yangang Wang, Wenjuan Zhao

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Molecular neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  4. Effect of uric acid in animal models of ischemic stroke: A systematic review and meta-analysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhongchao WangDepartment of Endocrinology, Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
Yanlin LinDepartment of Endocrinology, Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
Yuxiu LiuShandong Provincial Key Laboratory of Metabolic Disease, Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
Ying ChenDepartment of Endocrinology, Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
Bin WangDepartment of Endocrinology, Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
Changgui LiShandong Provincial Key Laboratory of Metabolic Disease, Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
Shengli YanDepartment of Endocrinology, Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
Yangang WangDepartment of Endocrinology, Affiliated Hospital of Qingdao University, Qingdao, 266003, China. nlwang@126.com.
Wenjuan ZhaoDepartment of Endocrinology, Affiliated Hospital of Qingdao University, Qingdao, 266003, China. zhaowjqdu@yeah.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies assessing the association between serum uric acid levels and neurological outcome after acute ischemic stroke reported conflicting results. A systematic review and meta-analysis were conducted to assess the impact of serum uric acid levels on outcome after acute ischemic stroke. Pubmed, Embase, Web of Science, and Google scholar were searched through September 26, 2014 to identify eligible published or unpublished studies on the association between serum uric acid levels and outcome after acute ischemic stroke. Hazard ratio (HR) for poor outcome or mean differences of serum uric acid levels with 95% confidence intervals (95% CIs) were pooled using meta-analysis. The primary outcome was occurrence of poor outcomes, while the secondary outcome was the mean differences of serum uric acid levels in patients with good or poor outcomes. Ten eligible studies with a total of 8131 acute ischemic stroke patients were included into the meta-analysis. Compared with low serum uric acid level, high serum uric acid level was associated better outcome after acute ischemic stroke (HR = 0.77, 95% CI 0.68-0.88, P = 0.0001). Sensitivity analysis further identified the prognostic role of serum uric acid levels on outcome after acute ischemic stroke. Patients with good outcomes had a higher serum uric acid level compared with those with poor outcome (mean difference = 30.61 μmol/L, 95% CI 20.13-41.08, P < 0.00001). There was no obvious risk of publication bias in the meta-analysis. This meta-analysis supports that serum uric acid level has a protective effect on neurological outcome after acute ischemic stroke. High uric acid level at the onset is a biomarker of better prognosis in patients with acute ischemic stroke.

Indexed as

Brain IschemiaHumansPublication BiasStrokeTreatment OutcomeUric AcidUric AcidOutcomesStrokeUric acid

Identifiers

PMID25744569

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.