ArticleScientific reports2015
Angiotensin-converting enzymes modulate aphid-plant interactions.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 67 citations in OpenAlex.
- Molecular and transcriptional regulation of plant defense responses to aphid infestation.Stress biology · 2026Review
- Article
- Identification of candidate host-manipulating effector genes in Aphis gossypii (Hemiptera: Aphididae) using a combination of transcriptome, genome, and differential gene expression data.Journal of insect science (Online) · 2025Article
- Molecular Interactions Between Plants and Aphids: Recent Advances and Future Perspectives.Insects · 2024Review
- A Comprehensive Transcriptomic and Proteomics Analysis of Candidate Secretory Proteins in Rose Grain Aphid,Current issues in molecular biology · 2024Article
- Roles of herbivorous insects salivary proteins.Heliyon · 2024Review
- A Method for Identification of Biotype-Specific Salivary Effector Candidates of Aphid.Insects · 2023Article
- Advances of herbivore-secreted elicitors and effectors in plant-insect interactions.Frontiers in plant science · 2023Review
- Role of Acrostyle Cuticular Proteins in the Retention of an Aphid Salivary Effector.International journal of molecular sciences · 2022Article
- Article
- Effector-mediated plant-virus-vector interactions.The Plant cell · 2022Review
- Control of aging by the renin-angiotensin system: a review ofFrontiers in pharmacology · 2022Review
- An update on angiotensin-converting enzyme 2 structure/functions, polymorphism, and duplicitous nature in the pathophysiology of coronavirus disease 2019: Implications for vascular and coagulation disease associated with severe acute respiratory syndrome coronavirus infection.Frontiers in microbiology · 2022Review
- Double-Strand RNA (dsRNA) Delivery Methods in Insects: Diaphorina citri.Methods in molecular biology (Clifton, N.J.) · 2022Article
- ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV.Clinical science (London, England : 1979) · 2020Review
- RNAi technology for management of banana bunchy top disease.Food and energy security · 2020Review
- Induced Systemic Resistance by a Plant Growth-Promoting Rhizobacterium Impacts Development and Feeding Behavior of Aphids.Insects · 2020Article
- Brown marmorated stink bug, Halyomorpha halys (Stål), genome: putative underpinnings of polyphagy, insecticide resistance potential and biology of a top worldwide pest.BMC genomics · 2020Article
- Toward a Comprehensive Pea Aphid Saliva-Proteomewith Insights from Transcripts from the WhiteflyBiochemistry & molecular biology journal · 2020Article
- Molecular Basis of Soybean Resistance to Soybean Aphids and Soybean Cyst Nematodes.Plants (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Angiotensin-converting enzymes (ACEs) are key components of the renin-angiotensin system in mammals. However, the function of ACE homologs in insect saliva is unclear. Aphids presumably deliver effector proteins via saliva into plant cells to maintain a compatible insect-plant interaction. In this study, we showed that ACE modulates aphid-plant interactions by affecting feeding behavior and survival of aphids on host plants. Three ACE genes were identified from the pea aphid Acyrthosiphon pisum genome. ACE1 and ACE2 were highly expressed in the salivary glands and are predicted to function as secretory proteins. The ACE2 transcript level decreased in aphids fed on artificial diet compared with aphids fed on Vicia faba. The knockdown of the expression of each ACE by RNAi failed to affect aphid survival. When ACE1 and ACE2 were simultaneously knocked down, aphid feeding was enhanced. Aphids required less time to find the phloem sap and showed longer passive ingestion. However, the simultaneous knockdown of ACE1 and ACE2 resulted in a higher mortality rate than the control group when aphids were fed on plants. These results indicated that ACE1 and ACE2 function together to modulate A. pisum feeding and survival on plants.
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Registered trials
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