ArticleWorld journal of surgery2015
Predictive factors for occult contralateral carcinoma in patients with unilateral papillary thyroid microcarcinoma by preoperative ultrasonographic and pathological features.
Article in World journal of surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 21 citations in OpenAlex.
- Analysis of risk factors and construction of a predictive model for contralateral occult carcinoma in patients with unilateral papillary thyroid carcinoma.Frontiers in endocrinology · 2025Article
- Extent of surgery for unilateral papillary thyroid cancer with nonsuspicious contralateral nodules by ultrasound.Endocrine · 2024Article
- Risk Factors for Contralateral Occult Papillary Thyroid Carcinoma in Patients with Clinical Unilateral Papillary Thyroid Carcinoma: A Case-Control Study.International journal of endocrinology · 2022Article
- Preoperative Serum Calcitonin Level and Ultrasonographic Characteristics Predict the Risk of Metastatic Medullary Thyroid Carcinoma: Functional Analysis of Calcitonin-Related Genes.Disease markers · 2022Article
- Prevalence and predictor for malignancy of contralateral thyroid nodules in patients with unilateral PTMC: a systematic review and meta-analysis.Endocrine connections · 2021Article
- Ultrasonographical, clinical and histopathological features of 1264 nodules with papillary thyroid carcinoma and microcarcinoma based on tumor size.Archives of endocrinology and metabolism · 2021Article
- Predictive factors of contralateral occult carcinoma in patients with papillary thyroid carcinoma: a retrospective study.Gland surgery · 2020Article
- Risk factor for contralateral occult carcinoma in patients with unilateral papillary thyroid carcinoma.Korean journal of clinical oncology · 2020Article
- How Many Contralateral Carcinomas in Patients with Unilateral Papillary Thyroid Microcarcinoma are Preoperatively Misdiagnosed as Benign?World journal of surgery · 2017Article
- The Extent of Surgery for Papillary Thyroid Microcarcinoma: The Controversy Continues.World journal of surgery · 2017Article
- Ultrasonographic risk factors of malignancy in thyroid nodules.Langenbeck's archives of surgery · 2016Article
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8 authors at 1 institution in 1 country.
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Abstract
backgroundThe surgical extent and indication for treatment in patients with papillary thyroid microcarcinoma (PTMC) remain a controversial issue. The aim of this study was to investigate the predictive factor for contralateral occult carcinoma in patients with unilateral PTMC by preoperative ultrasonographic and pathological features.
methodsOf the total patients who underwent thyroidectomy, 455 patients with PTMC confined to one unilateral lobe as diagnosed using preoperative ultrasonography (US) were enrolled in the study. Occult contralateral carcinoma was defined as tumor foci in the contralateral lobe that was not detected preoperatively, but was detected pathologically. All patients underwent preoperative US review to investigate the US features of PTMC such as laterality, location, size, internal component, echogenicity, margin, calcification shape, multifocality, bilaterality, extrathyroidal extension, and location with respect to the trachea. Clinicopathological data were also analyzed.
resultsOf the total of 455 patients who underwent total thyroidectomy for preoperatively detected unilateral PTMC, 71 patients (15.6 %) had contralateral occult carcinoma. Clinicopathological characteristics did not significantly differ between patients with and without contralateral occult carcinoma. Multivariate analysis showed that the absence of a well-defined margin and the presence of a probably benign nodule in the contralateral lobe were independent predictive factors for contralateral occult carcinoma in patients with unilateral PTMC in preoperative US images.
conclusionWe demonstrated that an absence of a well-defined margin and the presence of a probably benign nodule in the contralateral lobe were independent predictive factors for contralateral occult carcinoma in patients with unilateral PTMC in preoperative US. The prediction of contralateral occult carcinoma in unilateral PTMC using preoperative US features could be useful for determining the optical extent of surgery.
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