ArticleAmerican journal of ophthalmology2015
Ocular Involvement Following an Epidemic of Toxoplasma gondii Infection in Santa Isabel do Ivaí, Brazil.
Article in American journal of ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The role of age in ocular toxoplasmosis: clinical signs of immunosenescence and inflammaging.Frontiers in medicine · 2024Article
- Comparison of immunological and molecular methods for laboratory diagnosis of ocular toxoplasmosis in blood, serum and tears in Brazil.PloS one · 2024Article
- Outbreaks of clinical toxoplasmosis in humans: five decades of personal experience, perspectives and lessons learned.Parasites & vectors · 2021Review
- Screening for common eye diseases in the elderly with Optos ultra-wide-field scanning laser ophthalmoscopy: a pilot study with focus on ocular toxoplasmosis.International ophthalmology · 2021Article
- Interferon-γ and IL-10 Release Assay for Patients with Ocular Toxoplasmosis.The American journal of tropical medicine and hygiene · 2020Article
- Clinical and Multimodal Imaging Findings and Risk Factors for Ocular Involvement in a Presumed Waterborne Toxoplasmosis Outbreak, BrazilEmerging infectious diseases · 2020Article
- Evaluation of Serological and Molecular Tests Used for the Identification ofFrontiers in cellular and infection microbiology · 2019Article
- Public health risks associated with food-borne parasites.EFSA journal. European Food Safety Authority · 2018Article
- Treatment of Toxoplasmosis: Historical Perspective, Animal Models, and Current Clinical Practice.Clinical microbiology reviews · 2018Review
- Global initiative for congenital toxoplasmosis: an observational and international comparative clinical analysis.Emerging microbes & infections · 2018Review
- Symptomatic Acute Toxoplasmosis in Returning Travelers.Open forum infectious diseases · 2018Article
- Risk of Flood-Related Diseases of Eyes, Skin and Gastrointestinal Tract in Taiwan: A Retrospective Cohort Study.PloS one · 2016Article
- Article
- Clustering of Toxoplasma gondii Infections Within Families of Congenitally Infected Infants.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Article
- Ocular toxoplasmosis: lessons from Brazil.American journal of ophthalmology · 2015Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate ocular involvement (prevalence, incidence, lesion characteristics) following postnatally acquired infection with an "atypical" genotype of Toxoplasma gondii during a well-characterized 2001 outbreak in Santa Isabel do Ivaí, Brazil, attributed to a contaminated municipal reservoir.
designProspective longitudinal cohort study.
methodsWe performed ophthalmic examinations on 290 of 454 individuals with serologic evidence of T gondii infection during the epidemic (positive IgM antibody tests). Prevalence of ophthalmic findings (intraocular inflammatory reactions [including transient, isolated retinal whitening without clinically apparent retinal necrosis] and necrotizing retinochoroiditis) at initial examination (baseline) and incidence of new findings during 10.5 months of follow-up were calculated. Cumulative risks of ophthalmic events were determined (Kaplan-Meier technique).
resultsOcular involvement was present in 33 of 288 IgM+ individuals (11.5%) at baseline, including 17 with focal retinal whitening only and 13 with necrotizing retinochoroiditis. Incidence of new ocular involvement was estimated to be 1.73 events per 100 person-months (PM); cumulative risk at 10.5 months was 30.1%. Incident necrotizing retinochoroiditis was more common among those with focal retinal whitening at baseline (6.7/100 PM) than among those with no ocular involvement at baseline (1.11/100 PM; hazard ratio 6.07 [1.94-19.01]; P < .0001).
conclusionsWaterborne infection with an atypical genotype of T gondii is associated with substantial risk of ocular involvement. Lesions may continue to develop during the first year after infection. The increased risk of late necrotizing retinochoroiditis associated with isolated focal retinal whitening at presentation suggests the early presence of parasites in the retina, despite initial lack of observable retinal necrosis.
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