ArticleAJNR. American journal of neuroradiology2015
Narrowing the Expertise Gap for Predicting Intracranial Aneurysm Hemodynamics: Impact of Solver Numerics versus Mesh and Time-Step Resolution.
Article in AJNR. American journal of neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 85 citations in OpenAlex.
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- Comparative Analysis of Open-Source Finite Element Method Solvers for Computational Fluid Dynamics Performance in a Carotid Artery Model.Journal of biomechanical engineering · 2026Article
- Predicting Cerebral Aneurysm Rupture: The Role of Computational Fluid Dynamics.Neuroimaging clinics of North America · 2025Review
- Tube2FEM: a general-purpose highly automated pipeline for flow-related processes in (embedded) tubular objects.Royal Society open science · 2025Article
- Fast simulation of hemodynamics in intracranial aneurysms for clinical use.Acta neurochirurgica · 2025Article
- On flow fluctuations in ruptured and unruptured intracranial aneurysms: resolved numerical study.Scientific reports · 2024Article
- Flow-induced high frequency vascular wall vibrations in an arteriovenous fistula: a specific stimulus for stenosis development?Physical and engineering sciences in medicine · 2024Article
- Understanding intracranial aneurysm sounds via high-fidelity fluid-structure-interaction modelling.Communications medicine · 2023Article
- Onset and nature of flow-induced vibrations in cerebral aneurysms via fluid-structure interaction simulations.Biomechanics and modeling in mechanobiology · 2023Article
- Aneurysm Neck Overestimation has a Relatively Modest Impact on Simulated Hemodynamics.Cardiovascular engineering and technology · 2023Article
- Spiral Laminar Flow is Associated with a Reduction in Disturbed Shear in Patient-Specific Models of an Arteriovenous Fistula.Cardiovascular engineering and technology · 2023Article
- On the identification of hypoxic regions in subject-specific cerebral vasculature by combined CFD/MRI.Royal Society open science · 2023Article
- Machine Learning for Cardiovascular Biomechanics Modeling: Challenges and Beyond.Annals of biomedical engineering · 2022Review
- Medical Image-Based Computational Fluid Dynamics and Fluid-Structure Interaction Analysis in Vascular Diseases.Frontiers in bioengineering and biotechnology · 2022Review
- Aneurysm risk metrics and hemodynamics are associated with greater vessel wall enhancement in intracranial aneurysms.Royal Society open science · 2021Article
- Torrents of torment: turbulence as a mechanism of pulsatile tinnitus secondary to venous stenosis revealed by high-fidelity computational fluid dynamics.Journal of neurointerventional surgery · 2021Article
- Low Wall Shear Stress Is Associated with Saphenous Vein Graft Stenosis in Patients with Coronary Artery Bypass Grafting.Journal of cardiovascular translational research · 2021Article
- Numerical study on the energy cascade of pulsatile Newtonian and power-law flow models in an ICA bifurcation.PloS one · 2021Article
- Hemodynamic Abnormalities in the Aorta of Turner Syndrome Girls.Frontiers in cardiovascular medicine · 2021Article
- Hemodynamics of Cerebral Aneurysms: Connecting Medical Imaging and Biomechanical Analysis.Annual review of biomedical engineering · 2020Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeRecent high-resolution computational fluid dynamics studies have uncovered the presence of laminar flow instabilities and possible transitional or turbulent flow in some intracranial aneurysms. The purpose of this study was to elucidate requirements for computational fluid dynamics to detect these complex flows, and, in particular, to discriminate the impact of solver numerics versus mesh and time-step resolution. MATERIALS AND
methodsWe focused on 3 MCA aneurysms, exemplifying highly unstable, mildly unstable, or stable flow phenotypes, respectively. For each, the number of mesh elements was varied by 320× and the number of time-steps by 25×. Computational fluid dynamics simulations were performed by using an optimized second-order, minimally dissipative solver, and a more typical first-order, stabilized solver.
resultsWith the optimized solver and settings, qualitative differences in flow and wall shear stress patterns were negligible for models down to ∼800,000 tetrahedra and ∼5000 time-steps per cardiac cycle and could be solved within clinically acceptable timeframes. At the same model resolutions, however, the stabilized solver had poorer accuracy and completely suppressed flow instabilities for the 2 unstable flow cases. These findings were verified by using the popular commercial computational fluid dynamics solver, Fluent.
conclusionsSolver numerics must be considered at least as important as mesh and time-step resolution in determining the quality of aneurysm computational fluid dynamics simulations. Proper computational fluid dynamics verification studies, and not just superficial grid refinements, are therefore required to avoid overlooking potentially clinically and biologically relevant flow features.
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