ArticlePhysiological reports2015
Activity in descending dopaminergic neurons represents but is not required for leg movements in the fruit fly Drosophila.
Article in Physiological reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Article
- Descending control of motor sequences in Drosophila.Current opinion in neurobiology · 2024Review
- A Miniature Ultrasound Source for Neural Modulation.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Article
- Article
- On the Role of the Head Ganglia in Posture and Walking in Insects.Frontiers in physiology · 2020Review
- Targeted kinase inhibition relieves slowness and tremor in aNPJ Parkinson's disease · 2017Article
- Organization of descending neurons in Drosophila melanogaster.Scientific reports · 2016Article
- Comparative Neuroanatomy of the Lateral Accessory Lobe in the Insect Brain.Frontiers in physiology · 2016Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modulatory descending neurons (DNs) that link the brain to body motor circuits, including dopaminergic DNs (DA-DNs), are thought to contribute to the flexible control of behavior. Dopamine elicits locomotor-like outputs and influences neuronal excitability in isolated body motor circuits over tens of seconds to minutes, but it remains unknown how and over what time scale DA-DN activity relates to movement in behaving animals. To address this question, we identified DA-DNs in the Drosophila brain and developed an electrophysiological preparation to record and manipulate the activity of these cells during behavior. We find that DA-DN spike rates are rapidly modulated during a subset of leg movements and scale with the total speed of ongoing leg movements, whether occurring spontaneously or in response to stimuli. However, activating DA-DNs does not elicit leg movements in intact flies, nor do acute bidirectional manipulations of DA-DN activity affect the probability or speed of leg movements over a time scale of seconds to minutes. Our findings indicate that in the context of intact descending control, changes in DA-DN activity are not sufficient to influence ongoing leg movements and open the door to studies investigating how these cells interact with other descending and local neuromodulatory inputs to influence body motor output.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.